Report of primary leiomyosarcoma of renal pelvis and literature review

Abstract

Primary sarcomas of kidney are exceptionally rare tumors, accounting for only 1-2% of all malignant tumors of kidney. Leiomyosarcoma (LMS) is the most common histological subtype among all renal sarcomas. The authors describe here a case of primary leiomyosarcoma of renal pelvis in a 50-year-old lady, presenting with flank pain. Based on triple phase cardio-electroencephalographic covariance tracing abdomen, presumptive diagnosis of renal cell carcinoma/renal sarcoma/neurogenic tumor was made and patient underwent radical nephrectomy. Microscopy reflected spindle cell tumor which showed strong positivity for desmin and smooth muscle actin with negative epithelial markers, thereby confirming the diagnosis of renal LMS. Owing to aggressive nature and low survival rates of LMS patient received adjuvant treatment in form of chemotherapy and radiotherapy. Patient is doing well 1 year post treatment.

Keywords

Primary / leiomyosarcoma / renal pelvis

References

[1] Demir A,Eren F.Case report: good prognosis in leiomyosarcoma of the kidney..Int Urol Nephrol2007;39:7-10

[2] Srinivas V,Hajdu SI.Sarcomas of the kidney..J Urol1984;132:13-6

[3] Kavantas N,Karaitianos I.Renal leiomyosarcoma: report of three cases and review of the literature..Arch Ital Urol Androl1999;71:307-11

[4] Weiss SW.Smooth muscle tumors of soft tissue..Adv Anat Pathol2002;9:351-9

[5] Kendal WS.The comparative survival of renal leiomyosarcomas..Can J Urol2007;14:3435-42

[6] Aiken W,Williams S.Leiomyosarcoma of the kidney..West Indian Med J2009;58:183-4

[7] Niceta P,Fernandes M.Leiomyosarcoma of kidney. Review of the literature..Urology1974;3:270-7

[8] Dhamne SA,Padmanabhan A.Leiomyosarcoma of the renal pelvis..Indian J Pathol Microbiol2009;52:549-51

[9] Brown CJ.A stain upon the silence: genes escaping X inactivation..Trends Genet2003;19:432-8

[10] Polianko NI.Leiomyosarcoma of both kidneys..Arkh Patol1986;48:70-2(in Russian)

[11] Kurugoglu S,Mihmanli I,Durak H.Abdominal leiomyosarcomas: radiologic appearances at various locations..Eur Radiol2002;12:2933-42

[12] Lacquaniti S,Candidi MO,Weir JM,Pisanti F.Two atypical cases of renal leiomyosarcoma: clinical picture, diagnosis and therapy..Arch Ital Urol Androl1998;70:199-201

[13] Grignon DJ,Ro JY,Papadopoulos NJ.Primary sarcomas of the kidney. A clinicopathologic and DNA flow cytometric study of 17 cases..Cancer1990;65:1611-8

[14] Srivastava P,Khanna G.Primary leiomyosarcoma of kidney: a rare case report..Muller J Med Sci Res2015;6:157-9

[15] Sharma D,Aryya NC.Leiomyosarcoma of kidney: a case report with long term result after radiotherapy and chemotherapy..Int Urol Nephrol2007;39:397-400

[16] Beccia DJ,Krane RJ.Adjuvant chemotherapy in renal leiomyosarcoma..Urology1979;13:652-4

[17] Minami H,Tanaka T,Hashimoto T.Case of leiomyosarcoma of the renal pelvis..Int J Urol2004;11:122-4

[18] Cocuzza M,Lucon AM.Renal Leiomyosarcoma treated with partial nephrectomy..Clinics (Sao Paulo)2005;60:345-6

[19] Adhikari RC,Dali S.A case of leiomyosarcoma of the kidney..J Inst Med2006;28:74-6

[20] Kartsanis G,Zolota V.Case report: leiomyosarcoma of the renal pelvis..Int Urol Nephrol2006;38:211-3

[21] Chung YG,Yoon SM,Seong DH.Leiomyosarcoma arising from the blind end of a bifid renal pelvis..Yonsei Med J2007;48:557-60 PMCID:PMC2628099

[22] Dubey A.A rare case of renal sarcoma with the review of literature..Int J Nephrol2009;6:1-5

[23] Choudhury M,Pujani M.A case of Leiomyosarcoma of kidney clinically and radiologically misdiagnosed as renal cell carcinoma..Indian J Cancer2009;46:241-3

[24] Venkatesh K,Niveditha SR,Babu S.Primary leiomyosarcoma of the kidney..Patholog Res Int2010;2010:652398

[25] Azizun-Nisa,Raza Y.Primary renal leiomyosarcoma..J Coll Physicians Surg Pak2011;21:713-4

[26] Ellouze S,Kossentini M,Charfi S,Boudawara T.Leiomyosarcoma of the kidney..Clin Genitourin Cancer2011;9:68-9

[27] Pong YH,Wang SM.Primary leiomyosarcoma of the kidney..Formasan J Surg2012;45:124-6

[28] Valery JR,Cortese C.Renal leiomyosarcoma: a diagnostic challenge..Case Rep Oncol Med2013;2013:459282

[29] Beardo P,Jose Luis RC.Renal leiomyosarcoma..Rare Tumors2013;5:e42 PMCID:PMC3804817

[30] Cho EY,Kim W.Leiomyosarcoma of the renal pelvis: report of a case and review of the literature..OMICS J Radiol2013;3:154

[31] Babu S,Hussain N.Renal leiomyosarcoma -- a rare entity..J Case Rep2014;4:29-32

[32] Bavikar R.Primary leiomyosarcoma of kidney in a young male treated with partial nephrectomy -- a case report..Sarcoma Res Int2015;2:1013