An unusual case of encapsulated papillary carcinoma of breast

Abstract

Intracystic (encapsulated) papillary carcinoma of breast is a rare variant of breast cancer. It is usually a low-grade tumor showing estrogen, progesterone positivity. The authors report an unusual case of intracystic papillary carcinoma showing high nuclear grade, brisk mitosis, and necrosis with triple negativity for estrogen, progesterone, and Her-2/neu receptors, as well as negative axillary lymph nodes. Such cases need to be reported to increase awareness so that they will be managed conservatively, avoiding any overtreatment despite being high grade and triple negative.

Keywords

Key words: Intracystic papillary carcinoma / high grade / triple negative

References

[1] Reefy SA,Sada DA,Awadhi AA.Intracystic papillary breast cancer: a clinical update..Ecancermedicalscience2013;7:286

[2] Terzi A.An unusual case of invasive papillary carcinoma of the breast..Indian J Pathol Microbiol2012;55:543-5

[3] Ibarra JA.Papillary lesions of breast..Breast J2006;12:237-51

[4] Kuroda N,Inoue Mizuno K,Hamaguchi N.The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma..Med Mol Morphol2009;42:128-31

[5] Grabowski J,Sadler GR.Intracystic papillary carcinoma: a review of 917 cases..Cancer2008;113:916-20 PMCID:PMC2559962

[6] Collins LC.Papillary lesions of the breast: selected diagnostic and management issues..Histopathology2008;52:20-9

[7] Wynveen CA,Akram M,Norton L,Brogi E.Intracystic papillary carcinoma of the breast: an in situ or invasive tumor? Result of immunohistochemical analysis and clinical follow up..Am J Surg Pathol2011;35:1-4

[8] Ueng SH,Tavassoli FA.Papillary neoplasms of the breast: a review..Arch Pathol Lab Med2009;133:893-907

[9] Lefkowitz M,Wargotz ES.Intraductal (intracystic) papillary carcinoma of the breast and its variants: a clinicopathological study of 77 cases..Hum Pathol1994;25:802-9

[10] Solorazona CC,Hunt KK,Meric F,Ross MI,Feig BW,Singletary SE.Treatment and outcome of patients with intracystic papillary carcinoma of the breast..Am J Surg2002;184:364-8

[11] Mulligan AM.Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastases..Int J Surg Pathol2007;15:143-7

[12] Fayaju OM,Gillanders WE,Dietz JR,Margenthaler JA.Therapeutic management of intracystic papillary carcinoma of the breast: the role of radiation and endocrine therapy..Am J Surg2007;194:497-500