A cardio-hematopoietic signaling axis after myocardial infarction: platelet extracellular vesicles drive inflammatory remodeling

References

[1] Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective Nat Rev Cardiol 2020 17 773 89

[2] Imbesi A,Greco A,Spagnolo M.et al. Targeting inflammation after acute myocardial infarction J Am Coll Cardiol 2025 86 1146 69

[3] Nahrendorf M,Swirski FK. Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction? Eur Heart J 2016 37 868 72

[4] Swann JW,Olson OC,Passegué E. Made to order: emergency myelopoiesis and demand-adapted innate immune cell production Nat Rev Immunol 2024 24 596 613

[5] Buntsma N,van der Pol E,Nieuwland R,Gąsecka A. Extracellular Vesicles in Coronary Artery Disease. In: Xiao J, Editor. Extracellular vesicles in cardiovascular and metabolic diseases. Singapore: Springer Nature; 2023. pp. 81-103

[6] Ohayon-Steckel L,Zhang X,Haque S.et al. miR-499 in platelet-derived extracellular vesicles augments inflammatory cell generation and cardiac remodeling after myocardial infarction Circulation 2026 153 243 59

[7] Cai Z,Xie Q,Hu T.et al. S100A8/A9 in myocardial infarction: a promising biomarker and therapeutic target Front Cell Dev Biol 2020 8 603902

[8] Adachi T,Nakanishi M,Otsuka Y.et al. Plasma microRNA 499 as a biomarker of acute myocardial infarction Clin Chem 2010 56 1183 5

[9] Hu Z,Li W,Wei L,Ma J. Lactoferrin in cancer: focus on mechanisms and translational medicine Biochim Biophys Acta Rev Cancer 2025 1880 189330

[10] Boulanger CM,Loyer X,Rautou PE,Amabile N. Extracellular vesicles in coronary artery disease Nat Rev Cardiol 2017 14 259 72

[11] Ma Y,Dong S,Grippin AJ.et al. Engineering therapeutical extracellular vesicles for clinical translation Trends Biotechnol 2025 43 61 82

[12] Seyhan AA. Trials and tribulations of MicroRNA therapeutics Int J Mol Sci 2024 25 1469