Dysfunctional mitochondria elicit bioenergetic decline in the aged heart

Abstract

Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.

Keywords

Autophagy / cardiac aging / fibrosis / mitochondria / mitophagy / neurohormonal systems / oxidative stress / RAAS / ROS / sympathetic nervous system

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