Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes

Yuka Shiheido-Watanabe , Junichi Sadoshima

The Journal of Cardiovascular Aging ›› 2024, Vol. 4 ›› Issue (1) : 6

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The Journal of Cardiovascular Aging ›› 2024, Vol. 4 ›› Issue (1) :6 DOI: 10.20517/jca.2023.46
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Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes

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Yuka Shiheido-Watanabe, Junichi Sadoshima. Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes. The Journal of Cardiovascular Aging, 2024, 4(1): 6 DOI:10.20517/jca.2023.46

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Kim K,Yu YS.RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network.Nat Commun2017;8:162 PMCID:PMC5534431

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Kirshenbaum E,Margulets V,Nematisouldaragh D.Retinoic acid-related orphan receptors regulate autophagy and cell survival in cardiac myocytes during hypoxic stress.J Cardiovasc Aging2023;3:40

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Beak JY,Huang W.The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.J Biol Chem2021;297:101358 PMCID:PMC8626585

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