CaMKIIδ gene editing - A base hit for the heart

Christopher J. Walkey , William R. Lagor

The Journal of Cardiovascular Aging ›› 2023, Vol. 3 ›› Issue (2) : 19

PDF
The Journal of Cardiovascular Aging ›› 2023, Vol. 3 ›› Issue (2) :19 DOI: 10.20517/jca.2023.11
Commentary

CaMKIIδ gene editing - A base hit for the heart

Author information +
History +
PDF

Keywords

Base editing / heart / ischemia-reperfusion / aav / crispr

Cite this article

Download citation ▾
Christopher J. Walkey, William R. Lagor. CaMKIIδ gene editing - A base hit for the heart. The Journal of Cardiovascular Aging, 2023, 3(2): 19 DOI:10.20517/jca.2023.11

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Lebek S,Caravia XM.Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease.Science2023;379:179-85

[2]

Hausenloy DJ.Myocardial ischemia-reperfusion injury: a neglected therapeutic target.J Clin Invest2013;123:92-100 PMCID:PMC3533275

[3]

He BJ,Singh MV.Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.Nat Med2011;17:1610-8 PMCID:PMC3332099

[4]

Zhang R,Wu Y.Calmodulin kinase II inhibition protects against structural heart disease.Nat Med2005;11:409-17

[5]

van Oort RJ,Dixit SS.Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.Circulation2010;122:2669-79 PMCID:PMC3075419

[6]

Zhang T,Dalton ND.The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.Circ Res2003;92:912-9

[7]

Purohit A,Guan X.Oxidized Ca2+/calmodulin-dependent protein kinase II triggers atrial fibrillation.Circulation2013;128:1748-57 PMCID:PMC3876034

[8]

Erickson JR,Guan X.A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.Cell2008;133:462-74 PMCID:PMC2435269

[9]

Gaudelli NM,Rees HA.Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.Nature2017;551:464-71

[10]

Anzalone AV,Liu DR.Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors.Nat Biotechnol2020;38:824-44

[11]

Hakim CH,Pérez-López DO.Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.Nat Commun2021;12:6769 PMCID:PMC8613397

AI Summary AI Mindmap
PDF

68

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/