Mutant SRF and YAP1 remodel the chromatin to entice cardiac myocyte nuclear division

Keywords

Myocyte replication / transcription factor / hippo / regenerative medicine

References

[1] Bergmann O,Felker A.Dynamics of cell generation and turnover in the human heart.Cell2015;161:1566-75

[2] Xin M,Sutherland LB.Hippo pathway effector Yap promotes cardiac regeneration.Proc Natl Acad Sci USA2013;110:13839-44 PMCID:PMC3752208

[3] D’Uva G,Lauriola M.ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.Nat Cell Biol2015;17:627-38

[4] Mahmoud AI,Muralidhar SA.Meis1 regulates postnatal cardiomyocyte cell cycle arrest.Nature2013;497:249-53 PMCID:PMC4159712

[5] Xiang FL,Yutzey KE.Overexpression of Tbx20 in Adult cardiomyocytes promotes proliferation and improves cardiac function after myocardial infarction.Circulation2016;133:1081-92 PMCID:PMC4792775

[6] Xiao S,Muili AB.Mutant SRF and YAP synthetic modified mRNAs drive cardiomyocyte nuclear replication.J Cardiovasc Aging2022;2:29

[7] Chen CY.Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription.Mol Cell Biol1996;16:6372-84 PMCID:PMC231639

[8] Sepulveda JL,Iyer D,Schwartz RJ.Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity.J Biol Chem2002;277:25775-82

[9] Niu Z,Conway SJ.Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.Proc Natl Acad Sci USA2008;105:17824-9 PMCID:PMC2584699

[10] Zhou Q,Zhao B.The hippo pathway in heart development, regeneration, and diseases.Circ Res2015;116:1431-47 PMCID:PMC4394208

[11] Zhao B,Li W.Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.Genes Dev2007;21:2747-61 PMCID:PMC2045129

[12] Xiao S.STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.J Cardiovasc Aging2022;2:31