WNT links metabolism and cell cycle in postnatal cardiomyocytes

Keywords

WNT / cell cycle / metabolism / cardiomyocytes

References

[1] Qyang Y,Chiravuri M.The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.Cell Stem Cell2007;1:165-79

[2] Tzahor E.Wnt/beta-catenin signaling and cardiogenesis: timing does matter.Dev Cell2007;13:10-3

[3] Piven OO.The canonical way to make a heart: β-catenin and plakoglobin in heart development and remodeling.Exp Biol Med (Maywood)2017;242:1735-45 PMCID:PMC5714149

[4] Oerlemans MI,van Middelaar B,Doevendans PA.Active Wnt signaling in response to cardiac injury.Basic Res Cardiol2010;105:631-41 PMCID:PMC2916122

[5] Olcum M,Rouhi L.The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes.J Cardiovasc Aging2022;2:15 PMCID:PMC8874274

[6] Daskalopoulos EP,Blankesteijn WM.Targeting Wnt signaling to improve wound healing after myocardial infarction.Methods Mol Biol2013;1037:355-80

[7] Wang J,Lu A.Cardiomyocyte-specific deletion of β-catenin protects mouse hearts from ventricular arrhythmias after myocardial infarction.Sci Rep2021;11:17722 PMCID:PMC8421412

[8] Duan J,Liu D.Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair.EMBO J2012;31:429-42 PMCID:PMC3261567

[9] Masuelli L,Sacchetti P.Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts.Cardiovasc Res2003;60:376-87

[10] Bonda TA,Sokołowska M.Remodeling of the intercalated disc related to aging in the mouse heart.J Cardiol2016;68:261-8

[11] Yang K,Zhang H.The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.Lab Invest2016;96:116-36 PMCID:PMC4731283