Porcupine inhibition: a novel disease-modifier target in arrhythmogenic cardiomyopathy

Jose M. Lopez-Ayala

The Journal of Cardiovascular Aging ›› 2021, Vol. 1 ›› Issue (1) : 11

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The Journal of Cardiovascular Aging ›› 2021, Vol. 1 ›› Issue (1) :11 DOI: 10.20517/jca.2021.14
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Porcupine inhibition: a novel disease-modifier target in arrhythmogenic cardiomyopathy

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Jose M. Lopez-Ayala. Porcupine inhibition: a novel disease-modifier target in arrhythmogenic cardiomyopathy. The Journal of Cardiovascular Aging, 2021, 1(1): 11 DOI:10.20517/jca.2021.14

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References

[1]

Corrado D,Zorzi A.Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.Int J Cardiol2020;319:106-14

[2]

Austin KM,Chandler SF.Molecular mechanisms of arrhythmogenic cardiomyopathy.Nat Rev Cardiol2019;16:519-37 PMCID:PMC6871180

[3]

Garcia-Gras E,Giocondo MJ.Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.J Clin Invest2006;116:2012-21 PMCID:PMC1483165

[4]

Cheedipudi SM,Rouhi L.Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy.J Cardiovasc Aging2021;1:3

[5]

Musunuru K.Genome Editing: The recent history and perspective in cardiovascular diseases.J Am Coll Cardiol2017;70:2808-21 PMCID:PMC5742864

[6]

Rouhi L,Cheedipudi SM.The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure.Cardiovasc Res2021;cvab197:

[7]

Daskalopoulos EP.Effect of interventions in WNT signaling on healing of cardiac injury: a systematic review.Cells2021;10:207 PMCID:PMC7912185

[8]

Manolagas SC.Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.Mol Endocrinol2007;21:2605-14

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