Adenine base editing to treat progeria syndrome and extend the lifespan

Kiran Musunuru

The Journal of Cardiovascular Aging ›› 2021, Vol. 1 ›› Issue (1) : 8

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The Journal of Cardiovascular Aging ›› 2021, Vol. 1 ›› Issue (1) :8 DOI: 10.20517/jca.2021.10
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Adenine base editing to treat progeria syndrome and extend the lifespan

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Kiran Musunuru. Adenine base editing to treat progeria syndrome and extend the lifespan. The Journal of Cardiovascular Aging, 2021, 1(1): 8 DOI:10.20517/jca.2021.10

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Beyret E,Yamamoto M.Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome.Nat Med2019;25:419-22 PMCID:PMC6541418

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Anzalone AV,Liu DR.Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors.Nat Biotechnol2020;38:824-44

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Musunuru K,Mizoguchi T.In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.Nature2021;593:429-34

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