Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study

Xu Han , Hong Zhu

Journal of Biomedical Research ›› 2025, Vol. 39 ›› Issue (3) : 319 -324.

PDF (2714KB)
Journal of Biomedical Research ›› 2025, Vol. 39 ›› Issue (3) :319 -324. DOI: 10.7555/JBR.38.20240264
Letter to the Editor
research-article
Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study
Author information +
History +
PDF (2714KB)

Cite this article

Download citation ▾
Xu Han, Hong Zhu. Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study. Journal of Biomedical Research, 2025, 39(3): 319-324 DOI:10.7555/JBR.38.20240264

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Rassam Ghadhban B, Najim Abid F. The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital[J]. Ann Med Surg (Lond), 2019, 37: 7-10. doi: 10.1016/j.amsu.2018.11.017

[2]

Laukkarinen J, Sand J, Nordback I. The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones—a review[J]. HPB Surg, 2012, 2012: 102825. doi: 10.1155/2012/102825

[3]

Li Y, Liu H, Ye S, et al. The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study[J]. BMC Med, 2023, 21(1): 195. doi: 10.1186/s12916-023-02881-z

[4]

Lawlor DA, Harbord RM, Sterne JAC, et al. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology[J]. Stat Med, 2008, 27(8): 1133-1163. doi: 10.1002/sim.3034

[5]

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression[J]. Int J Epidemiol, 2015, 44(2): 512-525. doi: 10.1093/ije/dyv080

[6]

Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator[J]. Genet Epidemiol, 2016, 40(4): 304-314. doi: 10.1002/gepi.21965

[7]

Xu J, Zhang S, Tian Y, et al. Genetic causal association between iron status and osteoarthritis: a two-sample Mendelian randomization[J]. Nutrients, 2022, 14(18): 3683. doi: 10.3390/nu14183683

[8]

Zhang D, Hu Y, Guo W, et al. Mendelian randomization study reveals a causal relationship between rheumatoid arthritis and risk for pre-eclampsia[J]. Front Immunol, 2022, 13: 1080980. doi: 10.3389/fimmu.2022.1080980

[9]

Kulkarni V, Ramteke H, Lamture Y, et al. A review of synchronous findings of hypothyroidism and cholelithiasis[J]. Cureus, 2022, 14(10): e30316. doi: 10.7759/CUREUS.30316

[10]

Wang Y, Yu X, Zhao QZ, et al. Thyroid dysfunction, either hyper or hypothyroidism, promotes gallstone formation by different mechanisms[J]. J Zhejiang Univ Sci B, 2016, 17(7): 515-525. doi: 10.1631/jzus.B1500210

[11]

Joshi AD, Andersson C, Buch S, et al. Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies[J]. Gastroenterology, 2016, 151(2): 351-363. doi: 10.1053/j.gastro.2016.04.007

[12]

Kube I, Zwanziger D. Thyroid dysfunction and cholesterol gallstone disease[J]. Exp Clin Endocrinol Diabetes, 2020, 128(6-7): 455-461. doi: 10.1055/a-1033-7273

[13]

Ravi PC, Thugu TR, Singh J, et al. Gallstone disease and its correlation with thyroid disorders: a narrative review[J]. Cureus, 2023, 15(9): e45116. doi: 10.7759/CUREUS.45116

[14]

Song Y, Xu C, Shao S, et al. Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis[J]. J Hepatol, 2015, 62(5): 1171-1179. doi: 10.1016/j.jhep.2014.12.006

[15]

Villm JA, DeMonaco SM, Panciera DL, et al. Evaluation of gallbladder motility assessed by ultrasonography in dogs with hyperlipidemia[J]. J Vet Intern Med, 2023, 37(3): 968-975. doi: 10.1111/jvim.16713

[16]

Laukkarinen J, Sand J, Aittomäki S, et al. Mechanism of the prorelaxing effect of thyroxine on the sphincter of Oddi[J]. Scand J Gastroenterol, 2002, 37(6): 667-673. doi: 10.1080/00365520212492

[17]

Kube I, Tardio LB, Hofmann U, et al. Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids[J]. Thyroid, 2021, 31(6): 973-984. doi: 10.1089/thy.2020.0636

[18]

Morgan TH. Random segregation versus coupling in Mendelian inheritance[J]. Science, 1911, 34(873): 384. doi: 10.1126/science.34.873.384

PDF (2714KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/