Influence of national centralized drug procurement policy on the use of antibiotics in pediatric inpatients

Abstract

Objective: To explore the safety and efficacy of centrally procured antimicrobial drugs in the pediatric population, the impact of centrally procured policies on pediatric antimicrobial drug use and drug costs, and to make recommendations for hospitals to balance better the relationship between centralized procurement policies and antimicrobial drug management.

Methods: The data on the use of antimicrobial drugs and adverse reactions reported by inpatients in our hospital for half a year before and after centralized drug procurement were collected. Changes in the intensity, structure and utilization rate of antibacterial drugs, incidence of adverse reactions and drug costs, average length of stay, cure rate and improvement rate of patients before and after centralized procurement were compared. An electronic questionnaire survey was conducted on the cognition of clinical medical staff on the use of antibacterial drugs before and after centralized drug procurement.

Results: 1. Centralized antibacterial drugs are widely used in our hospital, and there is no obvious difference in safety and effectiveness from non-centralized drugs. 2. The centralized procurement policy significantly reduces antimicrobial drug costs but increases non-antimicrobial drug costs. 3. The intensity and utilization rate of antimicrobial drugs has stayed the same after the centralized procurement policy, but the drug structure changed.

Conclusion: There is still some prejudice among medical professionals and the public towards centralized antibacterial drugs, and positive guidance should be strengthened. The implementation of the centralized procurement policy needs corresponding management measures to ensure the rational use of antimicrobial drugs in clinic.

Keywords

Pediatrics / Antimicrobial drugs / Centralized procurement / Rational drug use

References

[1] General Office of the State Council. Notice of the General Office of the State Council on Printing and Distributing the Pilot Plan for the Centralized Purchase and Use of Drugs by the State Council. 2019 [No. 201912 [A].

[2] Tong RS, Zhao J, Wang MG, et al. Expert consensus on the management of centralized quantity procurement of antimicrobial drugs in healthcare institutions. Herald Med. 2023; 42 (1): 1- 5.

[3] Liu J, Yang DM, Zhang JJ. Effect of the centerized bidding system of drug on the use of antibacterials in five country public hospitals in Anhui Province. J Bengbu Med Coll. 2016; 41 (4): 527- 530.

[4] Guo L, Wang J, Wang JY, et al. Effects of VoIume—based procurement policy on the use of antibiotics in public hospital. Health Econ Res. 2022; 39 (6): 24- 29.

[5] Schrag SJ, Farley MM, Petit S, et al. Epidemiology of invasive early-onset neonatal sepsis. Pediatrics. 2005 to 2014;138(6), e20162013, 2016 Dec.

[6] Li Wei. Infection specialty committee of the neonatologist branch of the Chinese medical association, expert consensus on the diagnosis and management of neonatal sepsis (version 2019). Chin J Pediat. 2019; 57 (4): 252.

[7] Neonatal Infection: Antibiotics for Prevention and Treatment NICE Guideline. 2021.

[8] Yue Shaojie, Wang Mingjie, Jin Lin. Recommendations on the diagnosis and the use of antibiotics for early-onset sepsis in preterm infant: consensus of the expert panel from Hunan Province. Chin J Contemp Pediatr. 2020; 22 (1): 1- 6.

[9] Ni X. Dignosis and treatment guideline of community acquired pneumonia in children. Clin Educ General Pract. 2019; 17 (9): 771- 777.

[10] The Guiding Principles of Clinical Application of Antibiotics. 2015. The people's medical publishing house; 2015.

[11] Xiang ZJ, Chen XJ, Hu XJ, et al. Antibacterial drug use and drug resistance rate in a hospital after drug centralized Volume—based procurement. Centr South Pharm. 2022; 20 (11): 2678- 2683.

[12] Song X, Huang Z, Yang J, et al. Analyzing on the influence of national centralized drug procurement policy on the use of cephalosporins in liaoning province. Chin Health Serv Manag. 2023; 40 (2): 128- 131, 152.

[13] The state Council issued the 13th five-year plan for national food safety and the 13th five-year plan for national drug safety [EB/OL]. http://www.gov.on/zhengce/content/2017-02/21/content_5169755.htm; 2017-02-21.

[14] He Jiangjiang, Tang Mi, Cong Lixuan. The influence of centralized procurement and use of drugs on the management and use of clinical drugs. Chin Health Resour. 2021; 24 (1): 29- 31.

RIGHTS & PERMISSIONS

2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).