A critical review on zinc oxide nanoparticles: Synthesis, properties and biomedical applications

Suddhasattya Dey, Dibya lochan Mohanty, Noota Divya, Vasudha Bakshi, Anshuman Mohanty, Deepankar Rath, Sriparni Das, Arijit Mondal, Sourav Roy, Rajarshee Sabui

Intelligent Pharmacy ›› 2025, Vol. 3 ›› Issue (1) : 53-70.

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Intelligent Pharmacy ›› 2025, Vol. 3 ›› Issue (1) : 53-70. DOI: 10.1016/j.ipha.2024.08.004
Review article

A critical review on zinc oxide nanoparticles: Synthesis, properties and biomedical applications

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Abstract

Background: ZnO-NPs is an inorganic metal oxide that meets as medicine, a preservative in packaging, as well as an antibacterial agent without risk. The qualities of ZnO-NPs are influenced by their size, shape, concentration, and length of contact with the bacterial cell. There are many uses for ZnO including food technology, agriculture, cosmetology, optoelectronics, drug transporters, and antibacterial agents.

Methods: The antibacterial potential of ZnO-NPs mediated by plant extracts is superior against bacterial and fungal infections and human diseases. Trifolium, Justicia adhathoda, Physalis alkekengi L, Cassia auriculata, Pretence blossoms, Aloe barbadenis, Pongamia pinnata, Limoniaacidissima, Plectranthusamboinicus, Sedum alfredii Hance, and Aspidoterys cordata have all been discovered as excellent sources for the synthesis of NPs. ZnO-NPs is an inorganic metal oxide that meets the above-mentioned requirements, which can be utilised as medicine, a preservative in packaging, as well as an antibacterial agent without risk16. The qualities of ZnO-NPs are influenced by their size, shape, concentration, and length of contact with the bacterial cell.

Conclusion: It provides an overview of the numerous synthesis approaches, characterization techniques, and biomedical uses of organically generated ZnO-NPs in food, pharmaceutical and textile sectors. It has been discovered that ZnO-NPs produced by green synthesis are more useful for pharmacological and biological applications, particularly antimicrobials.

Keywords

ZnO-NPs / Green synthesis / Antimicrobial

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Suddhasattya Dey, Dibya lochan Mohanty, Noota Divya, Vasudha Bakshi, Anshuman Mohanty, Deepankar Rath, Sriparni Das, Arijit Mondal, Sourav Roy, Rajarshee Sabui. A critical review on zinc oxide nanoparticles: Synthesis, properties and biomedical applications. Intelligent Pharmacy, 2025, 3(1): 53‒70 https://doi.org/10.1016/j.ipha.2024.08.004

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