Evolution of pharmaceuticals using 3D and 4D printing

Abstract

This overview examines the latest developments and applications of 3D and 4D printing in the health care and pharmaceutical field. The technique of creating a 3D object from a 3D model in the required size and shape is known as 3D printing. Whereas, 4D printing is the establishment of intricate three-dimensional formations that can change form in response to various external inputs. Applying 3D printing technology 3D printing, the healthcare industry has produced significant strides toward a patient-centred approach. The future of biomedical science and patient-centered care could be completely transformed by 3D printing with further advancements in research and development. 3D, 4D Technology used in printing is one of the most advanced industrial technologies available worldwide. The 3D and 4D printing pharmaceutical enterprises have completed the shift from centralised to distributed systems for the purpose of creating dosage forms. The goal of the study is to support the research goal of determining the degree to which patient-specific treatment is enhanced and healthcare outcomes are improved through the use of printing technologies in pharmaceuticals. Beyond this thorough analysis, the study highlights potential and problems from several angles and comparative aspects between 3D and 4D printing.

Keywords

3D printing / 4D printing / Personalised medicine / Medication administration / Pharmaceutical applications

References

[1] Tracy Timothy , Wu Lei , et al. 3D printing: innovative solutions for patients and pharmaceutical industry. Int J Pharm. 2023;631:362–368.

[2] Islam Rofiqul , Sadhukhan Pinkan . An insight of 3d printing technology in pharmaceutical development and application: an updated review. Current Trends in pharmaceutical research. 2022;7:56–80.

[3] Haleem Abid , Javaid Mohd , et al. Significant roles of 4D printing using smart materials in the field of manufacturing. Advanced Industrial and Engineering Polymer Research. 2021;4:301–311.

[4] Shanthi Chede LR. Jaidev Chakka1. 3D printing of pharmaceuticals for disease treatment. Frontiers in Medical Technology. 2022;4. https://doi.org/10.3389/fmedt.2022.1040052.

[5] Wadher K, Trivedi R, et al. 3D printing in pharmaceuticals: an emerging technology full of challenges. Ann Pharm Fr. 2021;79:107–118.

[6] Ani Jose Preethy , Christoper Peter . 3d printing of pharmaceuticals – a potential technology in developing personalized medicine. Asian J Pharmaceut Res Dev. 2018;6:46–54.

[7] Carmen Alvarez-Lorenzo , Alvaro Goyanes , et al Cyclodextrins in 3D/4D printing for biomedical applications. Additive Manufacturing202;84:104120.

[8] Goole J, Amighi K. 3D printing in pharmaceutics: a new tool for designing customized drug delivery systems. Internaltional Journal of Pharmaceutics. 2016;29(1–2):376–394.

[9] Zheng D, Tang M, et al. 3D-printed ketoenamine crosslinked polyrotaxane hydrogels and their mechanochromic responsiveness. Polym Chem. 2023;14:2159–2163.

[10] Pita-Vilar M, Concheiro A, et al. Recent advances in 3D printed cellulose-based wound dressings: a review on in vitro and in vivo achievements. Carbohydr Polym. 2023;321:121298.

[11] pund Atul , Magar Manoj , Ahirrao Yogesh , et al. 3d printing technology: a customized advanced drug delivery. Asian J Pharmaceut Clin Res. 2022;15(8):23–33.

[12] Mahmoud DB, Schulz-Siegmund M. Utilizing 4D printing to design smart gastroretentive, esophageal, and intravesical drug delivery systems. Adv. Healthc. Mater. 2023:2202631.

[13] Bodani Urval Panchal , et al. Research paper fabrication of 3D printer. Int J Res Appl Sci Eng Technol. 2022;10(4):1156–1159.

[14] Lee BK, Yun YH, et al. Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system. Int J Pharm. 2012;427(2):305–310.

[15] Vaz VM, Kumar L. 3D printing as a promising tool in personalized medicine. The American Association of Pharmaceutical Scientists pharmscitech. 2021;22:49.

[16] Meléndez PA, Kane KM, Matteo Cerea , et al. Thermal inkjet application in the preparation of oral dosage forms: dispensing of prednisolone solutions and polymorphic characterization by solid-state spectroscopic techniques. J Pharmaceut Sci. 2008;97(7):2619–2636.

[17] Triadji Nugroho Wendy , Dong Yu , et al. Smart polyurethane composites for 3D or 4D printing: general-purpose use, sustainability and shape memory effect. Composites Part B. 2021;223:109104.

[18] Craniofac J, Ricci JL, et al. Three-dimensional printing of bone repair and replacement materials: impact on craniofacial surgery. Surg. 2012;23(1):304–308.

[19] Prasad LK, Smyth H. 3D Printing technologies for drug delivery: a review. Drug Dev Ind Pharm. 2016;42:1019–1031.

[20] Gazzaniga Andrea , Foppoli Anastasia , et al. Towards 4D printing in pharmaceutics. Int J Pharm. 2023;5.

[21] van der Klift Frank , Koga Yoichiro , et al. 3D printing of continuous carbon fibre reinforced thermo-plastic (CFRTP) tensile test specimens. Open J Compos Mater. 2016;6(1):18–27.

[22] Economidou SN, Lamprou DA, et al. 3D printing applications for transdermal drug delivery. Int J Pharm. 2018;544:415–424.

[23] Melocchi Alice , Uboldi Marco , et al. A graphical review on the escalation of fused deposition modeling (FDM) 3D printing in the pharmaceutical field, 3858. 2020;8(21):13.

[24] Wang J, Goyanes A, et al. 3D printing of oral modified-release dosage forms. Int J Pharm. 2016;503:207–212.

[25] Martinez PR, Goyanes A, et al. Fabrication of drug-loaded hydrogels with stereolithographic 3D printing. Int J Pharm. 2017;532:313–317.

[26] Mojtaba Falahati et al. Smart polymers and nanocomposites for 3D and 4D printing. Mater Today. 2020;40:215–245.

[27] Shinde Snehal , Mane Rutuja , et al. 4D printing: from emergence to innovation over 3D printing. Eur Polym J. 2023;197.

[28] Enke Marcel , Schwarz Nicolle , Gruschwitz Franka , et al. 3D screen printing technology enables fabrication of oral drug dosage forms with freely tailorable release profiles. Int J Pharm. 2023;642.

[29] Zhou Xueli , Ren Luquan , et al. Advances in 3D/4D printing of mechanical metamaterials: from manufacturing to applications. Composites Part B. 2023;254:110585.

[30] Li Yangyang , Zheng Wenhui , et al. Double-layer temperature-sensitive hydrogel fabricated by 4D printing with fast shape deformation. Colloids and Surfaces. Physicochemical and Engineering Aspects. 2022;648:3858.

[31] Shakor Pshtiwan , Sanjayan Jay , et al. Modified 3D printed powder to cement-based material and mechanical properties of cement scaffold used in 3D printing. Science Direct. 2017.

[32] Fouzan Iftekar Syed , Aabi Abdul , et al. Advancements and Limitations in 3D printing materials and technologies: a critical review. Polymers. 2023;15(11):2519.

[33] Mostafaei Amir , et al. Binder jet 3D printing—process parameters, materials, properties, modeling, and challenges. Prog Mater Sci. 2021;119:100707.

[34] Kumari Gourvi , Kumar Abhishek , et al. A voyage from 3D to 4D printing in nanomedicine and healthcare: part I. 2022;17(4):237–253.

[35] Hassan A. Alshahrani. Review of 4D printing materials and reinforced composites: behaviors, applications and challenges. J Sci: Advanced Materials and Devices. 2021;6:167–185.

[36] Sajjad Ramisha , Tahir Chauhdary Sohaib , et al. A review of 4D printing e Technologies, shape shifting, smart polymer based materials, and biomedical applications. Advanced Industrial and Engineering Polymer Research. 2024;7:20–36.

[37] Atta Islam , Bourauel Christoph , et al. Physiochemical and mechanical characterisation of orthodontic 3D printed aligner material made of shape memory polymers (4D aligner material). J Mech Behav Biomed Mater. 2024;150:106337.

[38] Leng J, Sha W, et al. Industry 5.0: prospect and retrospect. J Manuf Syst. 2022;65:279–295.

[39] Shinde Snehal , Mane Rutuja , et al. 4D printing: from emergence to innovation over 3D printing. Eur Polym J. 2023;197:112356.

[40] Mehta Parth , Sahlot Pankaj . Application of phase change materials in 4D printing: a review. Mater Today Proc. 2021;47:4746–4752.

[41] Peng Fua , Li Haimei , et al. 4D printing of polymers: techniques, materials, and prospects. Prog Polym Sci. 2022;126:101506.

[42] Demoly Frédéric , Dunn Martin L, et al. The status, barriers, challenges, and future in design for 4D printing. Mater Des. 2021;212:110193.

[43] Morley CD, Ding EA, et al. A balance between inter-and intra-microgel mechanics governs stem cell viability in injectable dynamic granular hydrogels. Adv. Materials. 2023;35:2304212.

[44] Iyengar KP, Zaw Pe E, et al. Industry 5.0 technology capabilities in trauma and orthopaedics. J Orthop. 2022;32:125–132.

[45] Pavan Kalyan BG, Mehrotra Sonal , et al. 3D printing in personalized medicines: a focus on applications of the technology. Mater Today. 2023;35:105875.

[46] Song Wenliang , Tang Yunxin , et al. Current developments of hypercrosslinked polymers as green carbon resources. Current Research in Green and Sustainable Chemistry. 2022;5:100335.

[47] Zhou JK, Feng HF, et al. Resistance-switchable conjugated polyrotaxane for flexible high-performance RRAMs. Materials horizon. 2022;9:1526–1535.

[48] Shen Lau Hui , Eugenia Angelica , et al. Recent advances in polymers of intrinsic microporosity (PIMs) membranes: delving into the intrinsic microstructure for carbon capture and arduous industrial applications. Prog Mater Sci. 2024;145:101297.

[49] Kumar Raman , Singh Rupinder , et al. Application of thermoplastic polymers in 4D printing. Encyclopedia of materials: plastics and. Polymers. 2022;1. https://doi.org/10.1016/B978-0-12-820352-1.00011-0.

[50] Ji S, Guvendiren M. Recent advances in bioink design for 3D bioprinting of tissues and organs. Front Bioeng Biotechnol. 2017;5:23.

[51] Gaurav Nazeer hasan , et al. Recent update of 3D printing technology in pharmaceutical formulation development. Journal of Biomaterials Science. 2021;32(42):1–26.

[52] Mohamadhoseini M, Mohamadnia Z. Supramolecular self-healing materials via host-guest strategy between cyclodextrin and specific types of guest molecules. Coord Chem Rev. 2021;432:213711.

[53] Hatami Hooman , Almahmeed Wael , et al. Exploring the potential of 3D and 4D printing in advancing stent manufacturing for cardiovascular diseases. Eur Polym J. 2024;212:113035.

[54] Alomari M, Vuddanda PR, et al. Printing T3 and T4 oral drug combinations as a novel strategy for hypothyroidism. Int J Pharm. 2018;549(1–2):363–369.

[55] Mallakpour Shadpour , Tabesh Farbod , et al. 3D and 4D printing: from innovation to evolution. Adv Colloid Interface Sci. 2021;294:102482.

[56] kumar Santosh , kumar Rakesh . Overview on 3D and 4D printing techniques and their emerging applications in medical sectors. Current Materials Science. 2023;16(2):143–170.

[57] Nakamura M, Iwanaga S, et al. Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Biofabrication. 2010;2(1):014110.

[58] Jiménez M, Romero L, et al. An overview about 3D printing methods and future prospects. Additive manufacturing technologies: Complexity. 2019.

[59] Minhaz Ahmad , Mohd Javaid , et al A study on fused deposition modeling (FDM) and laser-based additive manufacturing (LBAM) in the medical field. Intelligent Pharmacy.

RIGHTS & PERMISSIONS

2024 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.