A review of Vernonia cinerea L. ethno-medicinal uses and pharmacology shows that it could be a useful plant for medical purposes

D. Divya Theja, S. Nirmala

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Intelligent Pharmacy ›› 2024, Vol. 2 ›› Issue (5) : 662-671. DOI: 10.1016/j.ipha.2023.11.005

A review of Vernonia cinerea L. ethno-medicinal uses and pharmacology shows that it could be a useful plant for medical purposes

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Abstract

Vernonia cinerea L., also known as purple fleabane, is a plant with medicinal properties that have been traditionally used to treat respiratory infections, digestive disorders, and skin conditions. Its antimicrobial and anti-inflammatory properties make it a potential candidate for treating various infections and inflammatory diseases. The plant contains alkaloids, flavonoids, and essential oils, which possess antimicrobial properties, making it a promising candidate for treating bacterial and fungal infections. Its anti-inflammatory properties have shown potential for managing inflammatory diseases like arthritis and dermatitis. Additionally, the plant's analgesic and antipyretic effects suggest its potential for pain management and fever reduction. Its antioxidant properties make it a potential candidate for preventing and treating oxidative stress-related diseases like cardiovascular disorders and neurodegenerative conditions. However, more studies are needed to determine its optimal dosage, safety profile, and potential drug interactions before widespread use in medical practice.

Keywords

Vernonia cinerea / Bioactive compounds / Immunomodulatory / Anti-oxidant activity / Antimicrobial activity

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D. Divya Theja, S. Nirmala. A review of Vernonia cinerea L. ethno-medicinal uses and pharmacology shows that it could be a useful plant for medical purposes. Intelligent Pharmacy, 2024, 2(5): 662‒671 https://doi.org/10.1016/j.ipha.2023.11.005

References

[1]
Rajamurugan R, Selvaganabathy N, Kumaravel S, et al. Identification, quantification of bioactive constituents, evaluation of antioxidant andin vivoacute toxicity property from the methanol extract of Vernonia cinerea leaf extract. Pharmaceut Biol. 2011;49:1311–1320.
CrossRef Google scholar
[2]
Ik U. Effect of aqueous extract of bitter leaf (Vernonia amygdalina) against acetaminophen-induced liver damage in rats. Bioequival Bioavailabil Int J. 2018;2.
CrossRef Google scholar
[3]
Monton C, Kittiratpattana P, Nakyai S, et al. Microwave-assisted extraction of Clausena anisata leaves and Vernonia cinerea whole plants to maximize nitrate content: optimization approach, antioxidant activity, and cytotoxicity. Adv Traditionl Med. 2021;22:697–711.
CrossRef Google scholar
[4]
Subramaniyan NK, Elumalai K, Rajangam J, et al. Protective role of Vernonia cinerea against the Carmoisine induced brain injury and anxiogenic effect in mice. Egypt J Basic Appl Sci. 2022;10:12–24.
CrossRef Google scholar
[5]
Ngbolua K, Rakotoarimanana H, Rafatro H, et al. Comparative antimalarial and cytotoxic activities of two Vernonia species: V. amygdalina from the Democratic Republic of Congo and V. cinerea subsp vialis endemic to Madagascar. Int J Brain Cognit Sci. 2011;5.
CrossRef Google scholar
[6]
Maharajan M, Ahmed ABA, Taha RM, Jawahar S, Paul RR, Jayaseelan M. In vitro mass propagation from shoot tip explants of Vernonia cinerea less. An antioxidant, anti-inflammatory medicinal plant. Plant Tissue Cult Biotechnol. 1970;20:127–131.
CrossRef Google scholar
[7]
Aboubakar S, Souleymane S, Adama G, et al. Antiplasmodial activity of Vernonia cinerea (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria. Afr J Pharm Pharmacol. 2017;11:87–93.
CrossRef Google scholar
[8]
Alara OR, Abdurahman NH, Afolabi HK, Olalere OA. Efficient extraction of antioxidants from Vernonia cinerea leaves: comparing response surface methodology and artificial neural network. Beni-Suef Univ J Basic Appl Sci. 2018;7:276–285.
CrossRef Google scholar
[9]
Pakpisutkul J, Suwapraphan J, Sripayak N, et al. The effects of Vernonia cinerea extracts on antioxidant gene expression in colorectal cancer cells. Asian Pac J Cancer Prev APJCP. 2022;23:3923–3930.
CrossRef Google scholar
[10]
Monton C, Luprasong C. Effect of temperature and duration time of maceration on nitrate content of Vernonia cinerea: circumscribed central composite design and method validation. Int J Food Sci. 2019;2019:1–8.
CrossRef Google scholar
[11]
Prasopthum A, Pouyfung P, Sarapusit S, Srisook E, Rongnoparut P. Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. Drug Metabol Pharmacokinet. 2015;30:174–181.
CrossRef Google scholar
[12]
Pratheeshkumar P, Kuttan G. Vernolide-A, a sesquiterpene lactone Vernonia cinerea induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation. Drug Chem Toxicol. 2011;34:261–270.
CrossRef Google scholar
[13]
Alara OR, Abdurahman NH, Ukaegbu CI. Soxhlet extraction of phenolic compounds from Vernonia cinerea leaves and its antioxidant activity. J Appl Res Med Aromat Plants. 2018;11:12–17.
CrossRef Google scholar
[14]
Amuthan A, Devi V, Shreedhara CS, Rao V, Puri K, Jasphin S. Vernonia cinerea (neichitti keerai) regenerates proximal tubules in cisplatininduced renal damage in mice. Asian J Pharmaceut Clin Res. 2019;12:332.
CrossRef Google scholar
[15]
Ketsuwan N, Leelarungrayub J, Kothan S, Singhatong S. Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea. Drug Des Dev Ther. 2017;11:383–391.
CrossRef Google scholar
[16]
Alara OR, Abdurahman NH, Ukaegbu CI, Azhari NH. Vernonia cinerea leaves as the source of phenolic compounds, antioxidants, and anti-diabetic activity using microwave-assisted extraction technique. Ind Crop Prod. 2018;122:533–544.
CrossRef Google scholar
[17]
Pillai MJ, Dhande SR, Dhande RH. Investigations on anti-inflammatory and protective activity of Ethyl acetate fraction isolated from Vernonia cinerea (L) in Spargue Dawley rats. J Pharmacogn Phytochem. 2018;7:92–98.
CrossRef Google scholar
[18]
Jyotshna, Shanker K, Khare P, et al. Synthesis of gold mediated biocompatible nanocomposite of lactone enriched fraction from sahadevi (Vernonia cinerea): an assessment of antimalarial potential. Curr Top Med Chem. 2016;16:2043–2050.
CrossRef Google scholar
[19]
Thiagarajan VRK, Shanmugam P, Krishnan UM, Muthuraman A. Ameliorative potential of Vernonia cinerea on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. An Acad Bras Ciências. 2014;86:1435–1450.
CrossRef Google scholar
[20]
Krishnan SN, Talari D, Rajangam J, et al. Protective effect of Vernonia cinerea against sunset yellow induced anxiogenic behaviour in mice model: counteract oxidative damage based approach. Nat Prod J. 2021;11:537–545.
CrossRef Google scholar
[21]
Zhang M, Yang X, Wei Y, et al. Bioactive sesquiterpene lactones isolated from the whole plants of Vernonia cinerea. J Nat Prod. 2019;82:2124–2131.
CrossRef Google scholar
[22]
Pouyfung P, Choonate S, Wongnoppavich A, Rongnoparut P, Chairatvit K. Anti-proliferative effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8αTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation. Phytomedicine. 2019;52:238–246.
CrossRef Google scholar
[23]
Latha LY, Darah I, MohdJNMohd Kassim , Sasidharan S. Antibacterial activity and morphological changes of Pseudomonas aeruginosa cells after exposure to Vernonia cinerea extract. Ultrastruct Pathol. 2010;34:219–225.
CrossRef Google scholar
[24]
Chaikoolvatana A, Thanawirun J, Chaikoolvatana C, et al. The Innovation and Use of Vernonia Cinerea Jelly Candies for Smoking Cessation, Ubon Ratchathani Region, Thailand. vol. 3. Tobacco Prevention & Cessation;2017.
CrossRef Google scholar
[25]
Monton C, Sangprapai T, Mekwimonmas N, Sawangsang T, Chankana N, Luprasong C. Application of simplex lattice design in formulation development of lozenges containing Vernonia cinerea extract for smoking cessation. Key Eng Mater. 2019;819:227–232.
CrossRef Google scholar
[26]
Hassan ME, Mukherjee P, Kushwaha S, et al. First report of Lygaeid bugs (Hemiptera: lygaeidae) as a potential pollinator of little ironweed, Vernonia cinerea (Asteraceae). Int J Glob Sci Res. 2019;6.
CrossRef Google scholar
[27]
Kanthain R, Leelarungrayub J, Likhitsathian S, Natakankitkul S. Efficacy of combined relaxed deep-breathing with chest mobilization exercise and Vernonia cinerea -hard candy on smoking cessation and oxidative stress in active teenage smokers. Phcog J. 2023;14:720–727.
CrossRef Google scholar
[28]
Appadath Beeran A, Maliyakkal N, Rao CM, Udupa N. The enriched fraction of Vernonia cinerea. induces apoptosis and inhibits multi-drug resistance transporters in human epithelial cancer cells. J Ethnopharmacol. 2014;158:33–42.
CrossRef Google scholar
[29]
Mohamad Zani RA, Ahmad NH, Abdul Razak SR. Synthesis and characterisation of silver nanoparticles using Vernonia cinerea aqueous extract and their cytotoxicity activity against kasumi-1 cell line. J Teknol. 2016;78.
CrossRef Google scholar
[30]
Goyal PK, Verma SK, Sharma AK. Quantification of total phenolic and flavonoid contents, and evaluation of free radical scavenging potential of Vernonia cinerea. Asian Pacific J Health Sci. 2017;4:279–287.
CrossRef Google scholar
[31]
Sheelvanth Omkar , Bhande Prof Rajshekar , Farooq Ahmed Dr Md , Sreenivasa Rao Dr K. Evaluation of gastro-protective activity of ethanolic extract of roots of Vernonia cinerea. Int J Adv Res Sci Commun Technol. 2022:223–232.
CrossRef Google scholar
[32]
Tuenthosarn K, Budkaew J, Sorncha N, Chumworathayi B. Efficacy and safety of Vernonia cinerea for smoking cessation: an open-label randomized controlled trial. Asian Pac J Cancer Prev APJCP. 2023;24:101–109.
CrossRef Google scholar
[33]
Zulfiqar A, Zhang J, Cui X, Qian Y, Zhou X, Xie Y. A new begomovirus associated with alpha-and betasatellite molecules isolated from Vernonia cinerea in China. Arch Virol. 2011;157:189–191.
CrossRef Google scholar
[34]
Ramaswamy U, Mukundan D, Sreekumar A, Mani V. Green synthesis and characterization of silver nanoparticles using aqueous whole plant extract of Vernonia cinerea L. And its biological activities. Mater Today Proc. 2015;2:4600–4608.
CrossRef Google scholar
[35]
Chea A, Hout S, Long C, et al. Antimalarial activity of sesquiterpene lactones from Vernonia cinerea. Chem Pharm Bull. 2006;54:1437–1439.
CrossRef Google scholar
[36]
Thiagarajan VRK, Shanmugam P, Krishnan UM, Muthuraman A. Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats. Toxicol Ind Health. 2012;30:794–805.
CrossRef Google scholar
[37]
Pratheesh Kumar P, Kuttan G. Vernonia cinerea. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. Immunopharmacol Immunotoxicol. 2009;31:94–102.
CrossRef Google scholar
[38]
Brown SE, Been BO, McLaughlin WA. First report of lethal yellowing group (16Sr IV) of phytoplasmas in Vernonia cinerea in Jamaica. Plant Dis. 2008;92. 1132–1132.
CrossRef Google scholar
[39]
Misra TN, Singh RS, Upadhyay J, Srivastava R. Chemical constituents of Vernonia cinerea. Isolation and structure elucidation of a new pentacyclic triterpenoid. J Nat Prod. 1984;47:865–867.
CrossRef Google scholar
[40]
Misra TN, Singh RS, Upadhyay J, Srivastava R. Chemical constituents of Vernonia cinerea, Part I. Isolation and spectral studies of triterpenes. J Nat Prod. 1984;47:368–372.
CrossRef Google scholar
[41]
Johnson J, Varghese L. Tumor reduction potentials of Vernonia cinerea sesquiterpenes by induction of ferroptosis. J Herbs, Spices, Med Plants. 2023;29:438–451.
CrossRef Google scholar
[42]
Singh A, Bhandari A, Khatri A, Kumawat I, Saharan V. A pharmacognostical study of Vernonia cinerea (Asteraceae) and evaluation of anti-inflammatory and antibacterial activities of stem. Egypt Pharm J. 2014;13:104.
CrossRef Google scholar
[43]
Kuo Y, Kuo Y, Yu A, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. ChemInform. 2003;34.
CrossRef Google scholar
[44]
Miklossy G, Youn UJ, Yue P, Chang LC, Turkson J. Abstract 2694: novel sesquiterpene lactones derived from Vernonia cinerea inhibit STAT3 activity and suppress human glioblastoma phenotype. Cancer Res. 2014;74. 2694–2694.
CrossRef Google scholar
[45]
Alara OR, Abdurahman NH. Kinetics studies on effects of extraction techniques on bioactive compounds from Vernonia cinerea leaf. J Food Sci Technol. 2018;56:580–588.
CrossRef Google scholar
[46]
Bandyopadhyay R, Chakraborty S, Pramanik SK, Mukherjee A, Mandal B, Mitra B. Pattern of interaction of the pierid butterfly with Vernonia cinerea plant in urban habitat. Environ Ecol. 2023;41:1546–1551.
CrossRef Google scholar
[47]
Sahayaraj K, Roobadevi M, Rajesh S, Azizi S. Vernonia cinerea Less. silver nanocomposite and its antibacterial activity against a cotton pathogen. Res Chem Intermed. 2014;41:5495–5507.
CrossRef Google scholar
[48]
Rency R, Radhakrishnan V, Thomas A, Mohanan K. A study on callus induction and regeneration in Vernonia cinerea less. J Non-Timber For Prod. 2013;20:83–86.
CrossRef Google scholar
[49]
Mehta J, Joshi PM, Kushwaha P, Parkhe G. In-vitro antioxidant activity and antimicrobial activity of hydroalcoholic extracts of Vernonia cinerea. J Drug Deliv Therapeut. 2019;9:225–228.
CrossRef Google scholar
[50]
Chaikoolvatana A, Ayuthaya N, Suthipinittharm P, Chaikoolvatana C, Saisingh N, Manwong M. Development and Evaluation of the Effectiveness of Vernonia Cinerea (VC) Cookies for Smoking Cessation. vol. 3. Tobacco Prevention & Cessation;2017.
CrossRef Google scholar
[51]
Maheshwari P, Songara B, Kumar S, Jain P, Srivastava K, Kumar A. Alkaloid production in Vernonia cinerea: callus, cell suspension and root cultures. Biotechnol J. 2007;2:1026–1032.
CrossRef Google scholar
[52]
Asha R, Gayathri Devi V, Abraham A. Lupeol, a pentacyclic triterpenoid isolated from Vernonia cinerea attenuate selenite induced cataract formation in Sprague Dawley rat pups. Chem Biol Interact. 2016;245:20–29.
CrossRef Google scholar
[53]
Pouyfung P, Sarapusit S, Rongnoparut P. Effects of Vernonia cinerea compounds on drug-metabolizing cytochrome P450s in human liver microsomes. Phytother Res. 2017;31:1916–1925.
CrossRef Google scholar
[54]
Iwalewa EO, Iwalewa OJ, Adeboye JO. Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf. J Ethnopharmacol. 2003;86:229–234.
CrossRef Google scholar
[55]
Lestari S, Aryani RD, Palupi D. Pengaruh ketinggian tempat tumbuh terhadap kandungan fitokimia dan antioksidan ekstrak akar sawi langit (Vernonia cinerea.). Biotropica: J Trop Biol. 2021;5:84–93.
CrossRef Google scholar
[56]
Acharya R, Sharma B, Singh R, Jain P. Phytochemical and high-performance liquid chromatography analysis of extract of Vernonia cinerea. J Drug Deliv Therapeut. 2019;9:229–232.
CrossRef Google scholar
[57]
Taechowisan T, Singtotong C, Phutdhawong W. Antibacterial and antioxidant activities of acetogenins from streptomyces sp. VE2; an endophyte in Vernonia cinerea. J Appl Pharmaceut Sci. 2016;067–72.
CrossRef Google scholar
[58]
Ahsanul Haque Md . Evaluation of anti-diarrheal and anti-diabetic activities of the stem, barks and leaves of the plant Vernonia cinerea (Family: asteraceae). J Appl Pharmaceut Sci. 2013.
CrossRef Google scholar
[59]
Mazumder UK, Gupta M, Manikandan L, Bhattacharya S, Haldar PK, Roy S. Evaluation of anti-inflammatory activity of Vernonia cinerea. extract in rats. Phytomedicine. 2003;10:185–188.
CrossRef Google scholar
[60]
Dogra NK, Kumar S. A review on ethno-medicinal uses and pharmacology of Vernonia cinerea. Nat Prod Res. 2014;29:1102–1117.
CrossRef Google scholar
[61]
Latha RM, Geetha T, Varalakshmi P. Effect of Vernonia cinerea flower extract in adjuvant-induced arthritis. Gen Pharmacol Vasc Syst. 1998;31:601–606.
CrossRef Google scholar
[62]
Sonibare M, Aremu T, Okorie P. Micropropagation and evaluation of phenolic content, antioxidant and antimicrobial activities of Vernonia cinerea. Nigerian J Nat Prod Med. 2015;19:36–41.
CrossRef Google scholar
[63]
Sonibare MA, Aremu OT, Okorie PN. Antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea leaf extract. Afr Health Sci. 2016;16:629.
CrossRef Google scholar
[64]
Pandey G, Kasana V, Hore S. Spasmodic response and neurogenic mechanism of water extract of Vernonia cinerea. on rat duodenum. Planta Med. 2011;77.
CrossRef Google scholar
[65]
Goyal PK, Verma SK, Sharma AK. Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats. J Phytopharmacol. 2017;6:149–155.
CrossRef Google scholar
[66]
Pratheeshkumar P, Kuttan G. Antimetastatic potential of vernolide-A, a sesquiterpenoid from Vernonia cinerea. Hum Exp Toxicol. 2011;31:66–80.
CrossRef Google scholar
[67]
Jalalpure S, Hiremath R. Effect of hydro-alcoholic extract of Vernonia cinerea. against ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2016;48:434.
CrossRef Google scholar
[68]
Giby A. Pharmacognostical and phytochemical studies of the plant sahadevi [Vernonia cinerea.]. Int J Res Ayurveda Pharm. 2015;6:47–54.
CrossRef Google scholar
[69]
Misra T, Singh R, Srivastava R, Pandey H, Prasad C, Singh S. A new triterpenoidal from Vernonia cinerea. Planta Med. 1993;59:458–460.
CrossRef Google scholar
[70]
Pratheeshkumar P, Kuttan G. Vernonia cinerea less. Inhibits tumor cell invasion and pulmonary metastasis in C57bl/6 mice. Integr Cancer Ther. 2010;10:178–191.
CrossRef Google scholar
[71]
Evaluation Haque. Of the antioxidant and anti-cholineesterase activities of the stem, barks and leaves of the plant Vernonia cinerea (family: asteraceae). J Appl Pharmaceut Sci. 2012.
CrossRef Google scholar
[72]
Bashar Md. Preliminary phytochemical screenings and antipyretic, analgesic and anti-inflammatory activities of methanol extract of Vernonia cinerea less. (Fam: asteraceae). Eur J Med Plants. 2014;4:1178–1185.
CrossRef Google scholar
[73]
Tandon M, Shukla YN, Tripathi AK, Singh SC. Insect antifeedant principles from Vernonia cinerea. Phytother Res. 1998;12:195–199.
CrossRef Google scholar
[74]
Singh L, Antil R, Dahiya P. Antimicrobial and antioxidant potential of Vernonia cinerea extract coated AuNPs. Indian J Microbiol. 2021;61:506–518.
CrossRef Google scholar
[75]
Kuo Yang L, Tseng P, Liaw C, et al. Sesquiterpenoids from Taiwan people Vernonia cinerea. Planta Med. 2015;81.
CrossRef Google scholar
[76]
Chea A, Hout S, Long C, et al. Antimalarial activity of sesquiterpene lactones from Vernonia cinerea. ChemInform. 2007;38.
CrossRef Google scholar
[77]
Youn UJ, Wongwiwatthananukit S, Songsak T, Chang LC. Sesquiterpene lactones from Vernonia cinerea. Chem Nat Compd. 2018;54:235–237.
CrossRef Google scholar
[78]
Misra TN, Singh RS, Upadhyay J, Srivastava R. Isolation of a natural sterol and an aliphatic acid from Vernonia cinerea. Phytochemistry. 1984;23:415–417.
CrossRef Google scholar
[79]
Talukdar T. Taxonomic significance of cyspsela in Vernonia anthelmintica willd. And V. Cinerea less. (Asteraceae; tribe – vernonieae): structural manifestations. Plant Sci Today. 2015;2:107–115.
CrossRef Google scholar
[80]
Chen X, Zhan Z-J, Yue J-M. Sesquiterpenoids from Vernonia cinerea. Nat Prod Res. 2006;20:31–35.
CrossRef Google scholar
[81]
Pratheeshkumar P, Kuttan G. Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice. Inflammopharmacology. 2010;18:197–207.
CrossRef Google scholar
[82]
Chandra S. The ayurvedic drug sahdevi (Vernonia CinereaLess.). Q J Of Crude Drug Res. 1970;10:1566–1571.
CrossRef Google scholar
[83]
Dakshini KMM, Roonwal GS, Gupta SK. Heavy metal accumulation by Vernonia cinerea (L.) less. (asteraceae). J Geochem Explor. 1982;16:235–238.
CrossRef Google scholar
[84]
Naowaboot J, Wannasiri S, Pannangpetch P. Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice. Nutr Res. 2018;56:51–60.
CrossRef Google scholar
[85]
Chen X, Zhan Z-J, Yue J-M. Sesquiterpenoids from Vernonia cinerea. Nat Prod Res. 2006;20:125–129.
CrossRef Google scholar
[86]
Joshi RK. GC/MS analysis of the essential oil of Vernonia cinerea. Nat Prod Commun. 2015;10. 1934578X1501000.
CrossRef Google scholar
[87]
Panday G. Spasmodic response and neurogenic mechanism of water extract of Vernonia cinerea (L.) less on rat duodenum. J Appl Pharmaceut Sci. 2012. https://doi.org/10.7324/japs.2012.2909.
[88]
Yadava RN, Raj M. A new antiviral flavone glycoside from Vernonia cinerea less. Asian J Chem. 2013;25:3542–3544.
CrossRef Google scholar
[89]
Latha LY, Darah I, Jain K, Sasidharan S. Toxicity study of Vernonia cinerea. Pharmaceut Biol. 2009;48:101–104.
CrossRef Google scholar
[90]
Goggi A, Malpathak N. Antioxidant activities of root, stem and leaves of Vernonia cinerea (L) less. Free Radic Antioxidants. 2017;7:178–183.
CrossRef Google scholar
[91]
Joshi RK. Sesquiterpene rich essential oil of Vernonia cinerea Less. from India. South Afr J Bot. 2014;95:129–130.
CrossRef Google scholar
[92]
Chang LC, et al. ChemInform abstract: antiinflammatory sesquiterpene lactones from the flower of Vernonia cinerea. ChemInform. 2013;44.
CrossRef Google scholar
[93]
Gupta M, Mazumder UK, Manikandan L, Haldar PK, Bhattacharya S, Kandar CC. Antibacterial activity of Vernonia cinerea. Fitoterapia. 2003;74:148–150.
CrossRef Google scholar
[94]
Wu H, Pan Y. First report of powdery mildew caused by podosphaera xanthii on Vernonia cinerea in China. Plant Dis. 2023. https://doi.org/10.1094/pdis-05-23-0944-pdn.
[95]
St DS, Tk , Cinerea Vernonia . A review. J Curr Pharm Res. 2014;4:1194–1200.
CrossRef Google scholar
[96]
Mulyani E, Herlina Nahdiadwi M. Analisa kadar flavonoid fraksi etil asetat ekstrak ethanol tanaman sawi langit (Vernonia cinerea L) dengan metode spektrofotometri visible. Indones J Pharm Nat Prod. 2023;6:62–68.
CrossRef Google scholar
[97]
Saraphanchotiwitthaya A, Sripalakit P. Anti-inflammatory activity of a Vernonia cinerea methanolic extract in vitro. Sci Asia. 2015;41:392.
CrossRef Google scholar
[98]
Packialakshmi RM, Usha R. A simple and efficient method for agroinfection of Vernonia cinerea with infectious clones of Vernonia yellow vein virus. Virus Gene. 2011;43:465–470.
CrossRef Google scholar
[99]
Haque . Phytochemical investigation of Vernonia cinerea (family: asteraceae). J Appl Pharmaceut Sci. 2012. https://doi.org/10.7324/japs.2012.261.

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