An aqueous extract of Syzygium cumini bark reduces the rate of preterm birth in rats

M. Ramasamy; Karthikeyan E

doi:10.1016/j.ipha.2023.09.004

Intelligent Pharmacy ›› 2024, Vol. 2 ›› Issue (1) : 136 -143. DOI: 10.1016/j.ipha.2023.09.004

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An aqueous extract of Syzygium cumini bark reduces the rate of preterm birth in rats

M. Ramasamy ¹^,²^,³
, Karthikeyan E ³^,^†

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Abstract

Preterm delivery is a considerable burden on prenatal healthcare and a major risk factor for neurological impairment and disability. A study looked at whether an aqueous extract of Syzygium cumini (AESC) bark could stop rats from giving birth too early. The DPPH and ABTS radical scavenging assays were used to evaluate the antioxidant activity of AESC in vitro, and the results showed that this extract possesses free radical scavenging activity, which helps to prevent premature labour. A piece of an isolated rat uterus was used for in-vitro pharmacological testing of the AESC at 25 mg/ml and 50 mg/ml. The extract showed free radical scavenging activity, effectively suppressing uterine contractions by 45.7% and 66.9%, respectively. The researchers concluded that AESC has considerable tocolytic activity, resulting in a decrease in the rate of premature birth. The extract showed no significant adverse effects on mothers or their infants, suggesting it may be a safe option for pregnant individuals seeking to prevent preterm labor. The extract also exhibited a dose-dependent effect, with higher doses resulting in a greater reduction in premature birth rates, further supporting its efficacy as a tocolytic agent.

Keywords

Syzygium cumini / Tocolytic activity / Antioxidant activity / Preterm labor / Rat uterus muscle

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M. Ramasamy, Karthikeyan E. An aqueous extract of Syzygium cumini bark reduces the rate of preterm birth in rats. Intelligent Pharmacy, 2024, 2(1): 136-143 DOI:10.1016/j.ipha.2023.09.004

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