Chronomodulated drug delivery: Challenges, benefits, and future directions in asthma treatment

Abstract

This review discusses the challenges in drug delivery and the potential benefits of Chronomodulated drug delivery for antiasthmatic drugs. It explores new drugs, personalized medicine approaches, and future directions in asthma treatment, such as immunotherapy and gene therapy. The analysis also discusses the risks of gene therapy for severe asthma and its potential benefits, such as improved medication effectiveness and reduced side effects. Chronomodulated drug delivery, which involves administering medications at specific times to align with the body’s natural rhythms, has shown promising results in improving asthma control and reducing the frequency and severity of attacks. For instance, a study found that administering a Chronomodulated antiasthmatic drug in the morning, when lung function is typically at its lowest, significantly improved drug absorption and bioavailability compared to regular drug delivery. This optimized drug delivery not only enhanced the medication’s effectiveness but also reduced the need for frequent dosing and minimized side effects, leading to better overall asthma management.

Keywords

Chronomodulated drug delivery / Immunotherapy / Bioavailability / Asthma management

References

[1] Patil SS, Gupta VRM. Design and in vitro evaluation of multiparticulate system for the Chronomodulated delivery of lornoxicam. J Drug Deliv Therapeut. 2015;5(3).

[2] Beg S, Swain S, Gahoi S, Kohli K. Design, development and evaluation of chronomodulated drug delivery systems of amoxicillin trihydrate with enhanced antimicrobial activity. Curr Drug Deliv. 2013;10(2):174–187.

[3] Patil SS, Gupta VRM. Design, in vitro and in vivo evaluation of chronomodulated delivery systems of terbutaline sulphate for nocturnal asthama. J Drug Deliv Therapeut. 2016;6(3).

[4] Agarwal V, Bansal M. Chronomodulated delivery system: a tailored cap to fit different heads. Recent Pat Drug Deliv Formulation. 2012;6(2):171–180.

[5] Chenna R, Reddy YP. Formulation and in vivo evaluation of chronomodulated drug delivery of nimodipine. Int J Pharmaceut Sci Drug Res. 2019;11(6).

[6] Asiniparthi M. Formulation and evaluation of chronomodulated drug delivery of montelukast sodium. Global Journal of Pharmacy & Pharmaceutical Sciences. 2016;1(1).

[7] Alekya T, Narendar D, Mahipal D, Arjun N, Nagaraj B. Design and evaluation of chronomodulated drug delivery of tramadol hydrochloride. Drug Research. 2017;68(3):174–180.

[8] Chinthaginjala H, Ahad HA, Pradeepkumar B. Chronomodulated mucoadhesive gastroretentive drug delivery system of famotidine. Advances in Pharmacology and Pharmacy. 2022;10(3):209–217.

[9] Aldawsari HM, Naveen NR, Alhakamy NA, et al. Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization. Drug Deliv. 2022;29(1):2258–2268.

[10] Ns Krishna, Jayanthi B, Madhukar A. Formulation development and evaluation of chronomodulated drug delivery system by zafirlukast. Int J Appl Pharm. July 7, 2021:211–220.

[11] Salawi A. Self-emulsifying drug delivery systems: a novel approach to deliver drugs. Drug Deliv. 2022;29(1):1811–1823.

[12] Surti N, Naik S, Bagchi T, Dwarkanath BS, Misra A. Intracellular delivery of nanoparticles of an antiasthmatic drug. AAPS PharmSciTech. 2008;9(1):217–223.

[13] Elbatanony R. Pharmacokinetic evaluation of a chronotherapeutic system loaded with an antiasthmatic drug as an oral drug delivery system. Al-Azhar Journal of Pharmaceutical Sciences. 2016;53(1):198–206.

[14] Bisht R. Chronomodulated drug delivery system: a comprehensive review on the recent advances in a new sub-discipline of 0chronopharmaceutics. Asian J Pharm. 2011;5(1):1.

[15] Raina B, sharma P, Bhargava A, Sharma S, Sharma AR. Design and development of chronomodulated pulsincap delivery system of deflazacort. Asian Pacific Journal of Health Sciences. 2018;5(4):210–220.

[16] Sokar M, Hanafy A, Elkamel A, El-gamal S. Design of chronomodulated drug delivery system of valsartan: in vitro characterization. Indian J Pharmaceut Sci. 2015;77(4):470.

[17] Farooqui S. Alzheimer’s disease: delivery of drugs through intranasal route. J Drug Deliv Therapeut. 2016;6(6).

[18] Jain PG, Patil PP, Patil SD, Patil SD, Surana SJ. Evaluation of the antiasthmatic activity of methanolic extract of trigonella foenum graecum on experimental models of bronchial asthma. J Drug Deliv Therapeut. 2020;10(1):101–106.

[19] Chaudhary S, Parejiya P, Patel H, Shelat P. Chronomodulated drug delivery system of urapidil for the treatment of hypertension. International Journal of Pharmaceutical Investigation. 2015;5(2):107.

[20] Patil A, Masthiholimath V, Najwade B, Dandagi P, Gadad A. Development and characterization of chronomodulated drug delivery system of captopril. International Journal of Pharmaceutical Investigation. 2011;1(4):227.

[21] Solomon AO, Ukegbu Young C. Making drugs safer: improving drug delivery and reducing side-effect of drugs on the human biochemical system. Journal of Pharmaceutics & Drug Delivery Research. 2015;4(4). https://doi.org/10.4172/2325-9604.1000140.

[22] Mohammed WA, Ajin PK, Dhanapal Y. Chronomodulated drug delivery system of salmeterol fluticasone nlcs loaded tablets: preparation, characterization, stability and drug release studies for management of asthma. Asian Journal of Research in Pharmaceutical Sciences. 2021;11(2):95–102.

[23] Thirupathi G, Kumara Swamy S, Ramesh A. Solid lipid nanocarriers as alternative drug delivery system for improved oral delivery of drugs. J Drug Deliv Therapeut. 2020;10(6-s):168–172.

[24] Kharwade R, Nair H, Masurkar D, Pise A, More S, Pise S. Formulation and evaluation of chronomodulated pulsatile drug delivery system for nocturnal hyperacidity. Res J Pharm Technol. April 23, 2022:1449–1454.

[25] Koning GA, Storm G. Targeted drug delivery systems for the intracellular delivery of macromolecular drugs. Drug Discov Today. 2003;8(11):482–483.

[26] Morishita M, Peppas NA. Advances in oral drug delivery: improved bioavailability of poorly absorbed drugs by tissue and cellular optimization. Adv Drug Deliv Rev. 2012;64(6):479.

[27] Muzykantov VR. Biomedical aspects of targeted delivery of drugs to pulmonary endothelium. Expet Opin Drug Deliv. 2005;2(5):909–926.

[28] He W, Kapate N, Shields CW, Mitragotri S. Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases. Adv Drug Deliv Rev. 2020;165–166:15–40.

[29] Bichewar S, Pillai S, Mandloi RS, Birla N, Jain S. Formulation and evaluation of chronomodulated drug delivery system of doxofylline for treatment of nocturnal asthma. Res J Pharm Technol. 2020;13(12):6170–6175.

[30] Parmar K, Shaikh A, Dalvadi H. Chronomodulated drug delivery system of irbesartan: formulation and development using desing of experiment (DoE). Bull Fac Pharm Cairo Univ. 2018;56(1):11–17.

[31] Qureshi MJ, Ali J, Baboota S, Ahuja A, Mallikarjun C. Pharmacokinetic study of a capsule-based chronomodulated drug delivery system of salbutamol sulphate in rabbits. Trop J Pharmaceut Res. 2014;13(1):17.

[32] Patil S, Pund Joshi, Shahiwala A, Shishoo. Chronomodulated press-coated pulsatile therapeutic system for aceclofenac: optimization of factors influencing drug release and lag time. ChronoPhysiol Ther. February 2011:1.

[33] Manikkath J, Subramony JA. Toward closed-loop drug delivery: integrating wearable technologies with transdermal drug delivery systems. Adv Drug Deliv Rev. 2021;179:113997.

[34] Lemmer B. Chronobiology, drug-delivery, and chronotherapeutics. Adv Drug Deliv Rev. 2007;59(9-10):825–827.

[35] Leonaviciute G, Bernkop-Schnürch A. Self-emulsifying drug delivery systems in oral (poly) peptide drug delivery. Expet Opin Drug Deliv. 2015;12(11):1703–1716.

[36] Huang S, Huang G. Preparation and drug delivery of dextran-drug complex. Drug Deliv. 2019;26(1):252–261.

[37] Yong KS, Sung WK. Polymeric materials for advanced drug delivery. Adv Drug Deliv Rev. 2001;53(1):1–3.

[38] Yoshikawa H. Lymphatic delivery in ‘rectal drug delivery systems’. Adv Drug Deliv Rev. 1997;28(2):239–251.

[39] Gupta AK. Nasoadhesive drug delivery: a review. J Drug Deliv Therapeut. 2012;2(1).

[40] Arosio D, Casagrande C. Advancement in integrin facilitated drug delivery. Adv Drug Deliv Rev. 2016;97:111–143.

[41] Bianco S, Pieroni MG, Refini RM, Robuschi M, Vaghi A, Sestini P. Could NSAIDs have a role as antiasthmatic agents? Drugs. 1994;48(1):9–15.

[42] Utreja P, Jain S, Tiwary A K. Novel drug delivery systems for sustained and targeted delivery of anti-cancer drugs: current status and future prospects. Curr Drug Deliv. 2010;7(2):152–161.

[43] Kumar P, Mishra B. Colon targeted drug delivery systems -an overview. Curr Drug Deliv. 2008;5(3):186–198.

[44] Rao AR, Prabhakar MC. Screening methods for antiasthmatic agents. Methods Find Exp Clin Pharmacol. 2000;22(3):191.

[45] Lomia M. Bronchial asthma as neurogenic paroxysmal inflammatory disease: do some antiepileptic drugs have antiasthmatic properties? Med Hypotheses. 2007;69(4):858–859.

[46] Kumar L, Verma S, Singh M, Chalotra T, Utreja P. Advanced drug delivery systems for transdermal delivery of non-steroidal anti-inflammatory drugs: a review. Curr Drug Deliv. 2018;15(8):1087–1099.

[47] Wang S, Liu R, Fu Y, Kao WJ. Release mechanisms and applications of drug delivery systems for extended-release. Expet Opin Drug Deliv. 2020;17(9):1289–1304.

[48] Sowmya C, Lavakumar V, Venkateshan N, et al. Microcapsule-based chronomodulated drug delivery systems of montelukast sodium in the treatment of nocturnal asthma. International Journal of Pharmaceutical Investigation. 2018;8(1):24.

[49] Acharya G, Park K. Mechanisms of controlled drug release from drug-eluting stents. Adv Drug Deliv Rev. 2006;58(3):387–401.

RIGHTS & PERMISSIONS

2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.