Overcoming challenges of clinical cell therapies for Parkinson’s disease with photobiomodulation

Abstract

Photobiomodulation (PBM) has emerged as a rapidly growing and innovative therapeutic method for various illnesses in recent years. Due to the irreversible nature of Parkinson’s disease (PD), it has proven challenging to impede or postpone the progression of the disease. Despite research on pharmacological approaches to halt neuronal degeneration, the viability of these techniques has been called into doubt due to apprehensions over potential side effects and the ethical implications associated with the utilization of embryonic cell transplantation. Hence, developing an innovative therapeutic approach to halting neuronal degeneration and safeguarding neurons from this neurodegenerative disorder is imperative. This review examines the pathogenesis, challenges, and limitations of conventional PD therapies, allowing a closer examination of PBM’s distinctive approach within this medical context. Delving into PBM’s therapeutic mechanisms in the cells, the effects of different wavelengths on cell therapies in PD patients, and considerations for patient care administration to overcome traditional challenges, this study offers insights into its potential as a promising avenue for PD management.

Keywords

dopaminergic neurons / light therapy / neurodegenerative disease / photobiology

References

[1] P. S.Group, P. S.Group, JAMA 2000, 284, 1931.

[2] C.Marsden, J.Parkes, Lancet 1977, 309, 345.

[3] U.Kleinholdermann, B. Bacara, L.Timmermann, D. J.Pedrosa, Neuromodulation 2023, 26, 356.

[4] F.Salehpour, M. R.Hamblin, Biomolecules 2020, 10, 610.

[5] Y.-J.Wei, F. B.Palumbo, L.Simoni-Wastila, L. M.Shulman, B.Stuart, R.Beardsley, C.Brown, Clin. Ther. 2013, 35, 1513.

[6] I.Straka, M.Minár, M.Škorvánek, M.Grofik, K.Danterová, J.Benetin, E.Kurča, A.Gažová, V.Boleková, K. AWyman-Chick, J. Kyselovič, P.Valkovič, Front. Neurol. 2019, 10, 799.

[7] S.Mendorf, O. W.Witte, H.Zipprich, T. Prell, Front. Neurol. 2020, 11, 551696.

[8] J. W.Langston, L. S.Forno, J.Tetrud, A. G. Reeves, J. A.Kaplan, D.Karluk, Ann. Neurol. 1999, 46, 598.

[9] M. J.Soileau, F.Pagan, A.Fasano, R. Rodriguez-Cruz, L.Wang, P. L.Kandukuri, C. H.Yan, A.Alobaidi, Y.Bao, P.Kukreja, M.Oh, M. S.Siddiqui, Neurol. Ther. 2022, 11, 851.

[10] L.Santos, S.del Olmo-Aguado, P. L.Valenzuela, K.Winge, E.Iglesias-Soler, J.Argüelles-Luis, S.Álvarez-Valle, G. JParcero-Iglesias, A. Fernández-Martínez, A. Lucia, Brain Stimul. 2019, 12, 810.

[11] C.Hamilton, D.Hamilton, F.Nicklason, N.El Massri, Neural Regen. Res. 2018, 13, 1738.

[12] A. S. CFoo, T. W.Soong, T. T.Yeo, K. L. Lim, Front. Aging Neurosci. 2020, 12, 89.

[13] P. Y.Bikmulina, N. V.Kosheleva, A. I.Shpichka, P. S.Timashev, V. I.Yusupov, P. V.Maximchik, V. G.Gogvadze, Y. A.Rochev, Opt. Eng. 2020, 59, 061620.

[14] L. C.Gordon, D. M.Johnstone, Neural Regen. Res. 2019, 14, 2086.

[15] F.dos Santos Cardoso, F. Gonzalez-Lima, S. G.da Silva, Ageing Res. Rev. 2021, 70, 101415.

[16] C.-T.Hong, C. J.Hu, H. Y.Lin, D. Wu, Medicine 2021, 100, e24191.

[17] V.Ganeshan, N. V.Skladnev, J. Y.Kim, J.Mitrofanis, J.Stone, D. M.Johnstone, Neuroscience 2019, 400, 85.

[18] F.Salehpour, S.Gholipour-Khalili, F.Farajdokht, F.Kamari, T.Walski, M. R.Hamblin, J. O.DiDuro, P.Cassano, Rev. Neurosci. 2020, 31, 269.

[19] M. R.Hamblin, Biochemist 2016, 38, 24.

[20] J.Kaye, H.Gage, A.Kimber, L. Storey, P.Trend, Mov. Disord. 2006, 21, 1270.

[21] H. R.Morris, M. G.Spillantini, C. M.Sue, C. HWilliams-Gray, Lancet 2024, 403, 293.

[22] C. W.Olanow, C. G.Goetz, J. H.Kordower, A. J.Stoessl, V.Sossi, M. F.Brin, K. M. Shannon, G. M.Nauert, D. P.Perl, J.Godbold, T. B.Freeman, Ann. Neurol. 2003, 54, 403.

[23] Y.Ma, C.Tang, T.Chaly, P. Greene, R.Breeze, S.Fahn, C.Freed, V.Dhawan, D. Eidelberg, J. Nucl. Med. 2010, 51, 7.

[24] S. H.Shahmoradian, A. J. Lewis, C.Genoud, J.Hench, T. E.Moors, P. P.Navarro, D.Castaño-Díez, G.Schweighauser, A. Graff-Meyer, K. N.Goldie, R.Sütterlin, E. Huisman, A.Ingrassia, Y. d.Gier, A. J. M. Rozemuller, J.Wang, A. D.Paepe, J.Erny, A.Staempfli, J. Hoernschemeyer, F.Großerüschkamp, D.Niedieker, S. FEl-Mashtoly, M.Quadri, W. F. J. Van Ijcken, V.Bonifati, K.Gerwert, B.Bohrmann, S.Frank, M.Britschgi, H.Stahlberg, W. D. J.Van de Berg, M. E.Lauer, Nat. Neurosci. 2019, 22, 1099.

[25] E.Bossy-Wetzel, R.Schwarzenbacher, S. A.Lipton, Nat. Med. 2004, 10, S2.

[26] R. M.Ransohoff, A. E.Cardona, Nature 2010, 468, 253.

[27] C.Kobylecki, S. J.Counsell, N.Cabanel, T.Wächter, F. E.Turkheimer, K.Eggert, W.Oertel, D. J.Brooks, A.Gerhard, Parkinsonism Relat. Disord. 2013, 19, 527.

[28] G.Codolo, N.Plotegher, T.Pozzobon, M.Brucale, I.Tessari, L.Bubacco, M.de Bernard, PLoS One 2013, 8, e55375.

[29] D.Béraud, H. A. Hathaway, J.Trecki, S.Chasovskikh, D. A.Johnson, J. A.Johnson, H. J.Federoff, M.Shimoji, T. R.Mhyre, K. AMaguire-Zeiss, J. Neuroimmune Pharmacol. 2013, 8, 94.

[30] K.Belarbi, E.Cuvelier, M. A.Bonte, M.Desplanque, B.Gressier, D.Devos, M. CChartier-Harlin, Mol. Neurodegener. 2020, 15, 59.

[31] V.Brochard, B.Combadière, A.Prigent, Y.Laouar, A.Perrin, V.Beray-Berthat, O.Bonduelle, D.Alvarez-Fischer, J.Callebert, J. M.Launay, C.Duyckaerts, R. A.Flavell, E. C.Hirsch, S.Hunot, J. Clin. Invest. 2008, 119, 182.

[32] C. F.Orr, D. B.Rowe, Y.Mizuno, H. Mori, G. M.Halliday, Brain 2005, 128, 2665.

[33] C. T.Ekdahl, J. H.Claasen, S.Bonde, Z.Kokaia, O.Lindvall, Proc. Natl. Acad. Sci. USA 2003, 100, 13632.

[34] K.Belarbi, T.Jopson, D.Tweedie, C.Arellano, W.Luo, N. H.Greig, S. Rosi, J. Neuroinflammation 2012, 9, 23.

[35] D.Games, E.Valera, B.Spencer, E.Rockenstein, M.Mante, A.Adame, C. Patrick, K.Ubhi, S.Nuber, P.Sacayon, W.Zago, P.Seubert, R.Barbour, D.Schenk, E.Masliah, J. Neurosci. 2014, 34, 9441.

[36] D. B.Schenk, M.Koller, D. K.Ness, S. G.Griffith, M.Grundman, W.Zago, J.Soto, G.Atiee, S.Ostrowitzki, G. G.Kinney, Mov. Disord. 2017, 32, 211.

[37] J.Jankovic, I.Goodman, B.Safirstein, T. K.Marmon, D. B.Schenk, M.Koller, W.Zago, D. K.Ness, S. G.Griffith, M.Grundman, J.Soto, S.Ostrowitzki, F. G.Boess, M.Martin-Facklam, J. F.Quinn, S. H.Isaacson, O.Omidvar, A.Ellenbogen, G. G.Kinney, JAMA Neurol. 2018, 75, 1206.

[38] G.Mittermeyer, C. W.Christine, K. H.Rosenbluth, S. L.Baker, P.Starr, P.Larson, P. L. Kaplan, J.Forsayeth, M. J.Aminoff, K. S.Bankiewicz, Hum. Gene Ther. 2012, 23, 377.

[39] S.-i.Muramatsu, K. i.Fujimoto, S.Kato, H.Mizukami, S.Asari, K.Ikeguchi, T. Kawakami, M.Urabe, A.Kume, T.Sato, E.Watanabe, K. Ozawa, I.Nakano, Mol. Ther. 2010, 18, 1731.

[40] J.Eberling, W. J.Jagust, C. W.Christine, P.Starr, P.Larson, K. S.Bankiewicz, M. J.Aminoff, Neurology 2008, 70, 1980.

[41] M.Brys, L.Fanning, S.Hung, A.Ellenbogen, N.Penner, M.Yang, M.Welch, E.Koenig, E.David, T.Fox, S.Makh, J.Aldred, I. Goodman, B.Pepinsky, Y.Liu, D.Graham, A.Weihofen, J. M.Cedarbaum, Mov. Disord. 2019, 34, 1154.

[42] M.Mandler, E.Valera, E.Rockenstein, H.Weninger, C.Patrick, A.Adame, R.Santic, S.Meindl, B.Vigl, O.Smrzka, A.Schneeberger, F.Mattner, E.Masliah, Acta Neuropathol. 2014, 127, 861.

[43] A.Elkouzi, V.Vedam-Mai, R. S.Eisinger, M. S.Okun, Nat. Rev. Neurol. 2019, 15, 204.

[44] S.Palfi, J. M.Gurruchaga, H.Lepetit, K.Howard, G. S.Ralph, S.Mason, G. Gouello, P.Domenech, P. C.Buttery, P.Hantraye, N. J.Tuckwell, R. A.Barker, K. A.Mitrophanous, Hum. Gene Ther. Clin. Dev. 2018, 29, 148.

[45] V.Cochen, M.Ribeiro, J.Nguyen, J.Gurruchaga, G.Villafane, C.Loc’h, G.Defer, Y.Samson, M.Peschanski, P.Hantraye, P.Cesaro, P.Remy, Mov. Disord. 2003, 18, 928.

[46] I.Straka, M.Minar, M.Grofik, M. Skorvanek, V.Bolekova, A.Gazova, J.Kyselovic, P.Valkovic, J. Pers. Med. 2022, 12, 179.

[47] P.Brundin, O.Pogarell, P.Hagell, P.Piccini, H.Widner, A.Schrag, A.Kupsch, L.Crabb, P.Odin, B. Gustavii, A.Björklund, D. J.Brooks, C. D.Marsden, W. H.Oertel, N. P.Quinn, S.Rehncrona, O.Lindvall, Brain 2000, 123, 1380.

[48] T. B.Freeman, C. W.Olanow, R. A.Hauser, G. M.Nauert, D. A.Smith, C. V.Borlongan, P. R.Sanberg, D. A.Holt, J. H.Kordower, F. J. G.Vingerhoets, B. J. Snow, D.Calne, L. L.Gauger, Ann. Neurol. 1995, 38, 379.

[49] C.Marsden, J.Parkes, J.Rees, Lancet 1973, 302, 1459.

[50] U.Rinne, P.Mölsä, Neurology 1979, 29, 1584.

[51] D. J.Brooks, J. Neurol. Neurosurg. Psychiatry 2000, 68, 685.

[52] D. R.Brocks, J. Pharm. Pharm. Sci. 1999, 2, 39.

[53] E.Cereda, R.Cilia, M.Canesi, S. Tesei, C. B.Mariani, A. L.Zecchinelli, G. Pezzoli, J. Neurol. 2017, 264, 1254.

[54] S.Kaakkola, Drugs 2000, 59, 1233.

[55] U.Wüllner, T.Schmitz-Hübsch, G.Antony, R.Fimmers, A.Spottke, W. H.Oertel, G.Deuschl, T.Klockgether, K.Eggert, Eur. J. Neurol. 2007, 14, 1405.

[56] H.Braak, K. D.Tredici, U.Rüb, R. A.de Vos, E. N.Jansen Steur, E.Braak, Neurobiol. Aging 2003, 24, 197.

[57] H.Braak, R. A.de Vos, J.Bohl, K.Del Tredici, Neurosci. Lett. 2006, 396, 67.

[58] M.Politis, K.Wu, C.Loane, N. P. Quinn, D. J.Brooks, W. H.Oertel, A.Björklund, O.Lindvall, P.Piccini, Sci. Transl. Med. 2012, 4, 128ra41.

[59] P. A.De Sousa, D.Ritchie, A.Green, S.Chandran, R.Knight, M. W.Head, Acta Neuropathol. 2019, 137, 363.

[60] A. L.Perrier, V.Tabar, T.Barberi, M. E. Rubio, J.Bruses, N.Topf, N. L.Harrison, L.Studer, Proc. Natl. Acad. Sci. USA 2004, 101, 12543.

[61] F.Stocchi, D.Badiali, L.Vacca, L.D’Alba, F.Bracci, S.Ruggieri, M.Torti, A.Berardelli, E.Corazziari, Mov. Disord. 2000, 15, 71.

[62] R. D.Abbott, G. W.Ross, H.Petrovitch, C. M.Tanner, D. G.Davis, K. H.Masaki, L. J. Launer, J. D.Curb, L. R.White, Mov. Disord. 2007, 22, 1581.

[63] R. D.Abbott, H.Petrovitch, L. R.White, K. H.Masaki, C. M.Tanner, J. D.Curb, A.Grandinetti, P. L.Blanchette, J. S.Popper, G. W.Ross, Neurology 2001, 57, 456.

[64] C.Haikal, Q.-Q.Chen, J.-Y.Li, Transl. Neurodegener. 2019, 8, 1.

[65] D. D.Spencer, R. J.Robbins, F.Naftolin, K. L.Marek, T.Vollmer, C.Leranth, R. H.Roth, L. H.Price, A.Gjedde, B. S. Bunney, K. J.Sass, J. D.Elsworth, E. L.Kier, R.Makuch, P. B. Hoffer, D. E.Redmond, Jr., N. Engl. J. Med. 1992, 327, 1541.

[66] J. M.McCune, I. L.Weissman, Stem Cell Rep. 2019, 13, 777.

[67] R. A.Barker, M.Parmar, L.Studer, J.Takahashi, Cell Stem Cell 2017, 21, 569.

[68] N.El Massri, A. P.Lemgruber, I. J.Rowe, C.Moro, N.Torres, F.Reinhart, C.Chabrol, A. L.Benabid, J.Mitrofanis, Exp. Brain Res. 2017, 235, 1861.

[69] M. TWong-Riley, H. L.Liang, J. T.Eells, B. Chance, M. M.Henry, E.Buchmann, M.Kane, H. T.Whelan, J. Biol. Chem. 2005, 280, 4761.

[70] M. TWong-Riley, X.Bai, E.Buchmann, H. T. Whelan, Neuroreport 2001, 12, 3033.

[71] M. H.Berman, T. W.Nichols, Photobiomodul. Photomed. Laser Surg. 2019, 37, 623.

[72] C.Tsai, SOJ Complement. Emerg. Med. 2022, 2, 1.

[73] J.Bullock-Saxton, A. Lehn, E.Laakso, J. Alzheim. Dis. 2021, 83, 1499.

[74] D.Mintzopoulos, T. E.Gillis, C. E.Tedford, M. J.Kaufman, Photomed. Laser Surg. 2017, 35, 395.

[75] D.Li, H.Lin, S.Sun, S. Liu, Z.Liu, Y.He, J.Zhu, J.Xu, O.Semyachkina-Glushkovskaya, T.Yu, D.Zhu, Front. Optoelectron. 2023, 16, 45.

[76] V. E.Shaw, S.Spana, K.Ashkan, A. L. Benabid, J.Stone, G. E.Baker, J.Mitrofanis, J. Comp. Neurol. 2010, 518, 25.

[77] C.Peoples, V. E.Shaw, J.Stone, G. Jeffery, G. E.Baker, J.Mitrofanis, ISRN Neurol. 2012, 2012, 850150.

[78] V. E.Shaw, C.Peoples, S.Spana, K.Ashkan, A.-L.Benabid, J.Stone, G. E.Baker, J.Mitrofanis, Park. Dis. 2012, 2012, 296875.

[79] C.Peoples, S.Spana, K.Ashkan, A.-L. Benabid, J.Stone, G. E.Baker, J.Mitrofanis, Park. Relat. Disord. 2012, 18, 469.

[80] C.Moro, N.Torres, N.El Massri, D.Ratel, D. M.Johnstone, J.Stone, J.Mitrofanis, A.-L.Benabid, BMC Neurosci. 2013, 14, 40.

[81] C.da Luz Eltchechem, A. S. I. Salgado, R. A.Zângaro, M. C.da Silva Pereira, I. I. Kerppers, L. A.da Silva, R. B.Parreira, Lasers Med. Sci. 2017, 32, 749.

[82] A.Pitzschke, B.Lovisa, O.Seydoux, M.Zellweger, M.Pfleiderer, Y.Tardy, G.Wagnières, Phys. Med. Biol. 2015, 60, 2921.

[83] M.Yang, Z.Sun, Z.Yang, Neural Regen. Res. 2021, 16, 1177.

[84] C. L.Hamilton, H.El Khoury, D.Hamilton, F.Nicklason, J.Mitrofanis, Photobiomodul. Photomed. Laser Surg. 2019, 37, 615.

[85] B.Ahrabi, F. S.Tabatabaei Mirakabad, S.Niknazar, A. A.Payvandi, N.Ahmady Roozbahany, M.Ahrabi, S. D.Torkamani, H. A.Abbaszadeh, J. Laser Med. Sci. 2022, 13, e28.

[86] C.Hamilton, D.Hamilton, F.Nicklason, J.Mitrofanis, in Photobiomodulation in the Brain (Eds: M. R. Hamblin, Y.-Y. Huang), Academic Press 2019, pp. 463–472.

[87] M. R.Hamblin, BBA Clin. 2016, 6, 113.

[88] A.Oueslati, B.Lovisa, J.Perrin, G.Wagnières, H. van den Bergh, Y.Tardy, H. A.Lashuel, PLoS One 2015, 10, e0140880.

[89] D. J.Gendron, M. R.Hamblin, Photobiomodul. Photomed. Laser Surg. 2019, 37, 408.

[90] K.Montazeri, M.Farhadi, R.Fekrazad, Z.Akbarnejad, S.Chaibakhsh, S.Mahmoudian, J. Photochem. Photobiol. B Biol. 2021, 221, 112207.

[91] C.Petrucco, P.Benson, L.Gordon, J.Stone, D. M.Johnstone, in Diagnosis and Management in Parkinson’s Disease (Eds: C. R. Martin, V. R. Preedy), Academic Press 2020, pp. 697–712.

[92] D. M.Johnstone, C.Moro, J.Stone, A. L. Benabid, J.Mitrofanis, Front. Neurosci. 2016, 9, 500.

[93] A.Liebert, B.Bicknell, E. L.Laakso, G.Heller, P.Jalilitabaei, S.Tilley, J.Mitrofanis, H.Kiat, BMC Neurol. 2021, 21, 256.

[94] B.Bicknell, A.Liebert, G.Herkes, J. Pers. Med. 2024, 14, 112.

[95] P. A.Trimmer, K. M.Schwartz, M. K.Borland, L. D.Taboada, J.Streeter, U.Oron, Mol. Neurodegener. 2009, 4, 26.

[96] B. J.Quirk, K. D.Desmet, M.Henry, E.Buchmann, M.Wong-Riley, J. T.Eells, H. T.Whelan, Front. Biosci. 2012, 4, 818.

[97] R.Maloney, S.Shanks, J.Maloney, Lasers Surg. Med. 2010, 61.

[98] A.Liebert, B.Bicknell, E.-L.Laakso, P.Jalilitabaei, S.Tilley, H.Kiat, J.Mitrofanis, Photobiomodul. Photomed. Laser Surg. 2022, 40, 112.

[99] V. M.Holanda, M. C.Chavantes, D. F. T.Silva, C. V. M.de Holanda, J. O. de Oliveira, Jr., X.Wu, J. J.Anders, Laser Surg. Med. 2016, 48, 653.

[100] A. L.Boxer, J. T.Yu, L. I.Golbe, I. Litvan, A. E.Lang, G. U.Höglinger, Lancet Neurol. 2017, 16, 552.

[101] G.Herkes, C.McGee, A.Liebert, B. Bicknell, V.Isaac, H.Kiat, C. S.McLachlan, eClinicalMedicine 2023, 66, 102338.

[102] F.Schiffer, A. L.Johnston, C.Ravichandran, A.Polcari, M. H.Teicher, R. H.Webb, M. R.Hamblin, Behav. Brain Funct. 2009, 5, 1.

[103] J.Mitrofanis, Neural Regen. Res. 2017, 12, 574.

[104] D. M.Johnstone, C.Moro, N.Torres, J. Eells, G. E.Baker, K.Ashkan, J.Stone, A.-L.Benabid, J.Mitrofanis, K.Coleman, ChronoPhysiol. Ther. 2014, 4, 1.

[105] J. M.Mack, M. G.Schamne, T. B.Sampaio, R. A. N.Pértile, P. A. C. M.Fernandes, R. P. Markus, R. D.Prediger, Oxid. Med. Cell. Longev. 2016, 2016, 3472032.

[106] U.Maitra, J.Conger, M. M. M.Owens, L.Ciesla, Neurotoxicology 2023, 96, 1.

[107] F.Blandini, G.Nappi, C.Tassorelli, E.Martignoni, Prog. Neurobiol. 2000, 62, 63.

[108] H.Bergman, G.Deuschl, Mov. Disord. 2002, 17, S28.

[109] X.Hu, J.Li, X.Wang, H. Liu, T.Wang, Z.Lin, N.Xiong, Antioxidants 2023, 12, 396.

[110] A.Spinella, M.de Pinto, C.Galluzzo, S.Testoni, P.Macripò, F.Lumetti, L.Parenti, L.Magnani, G.Sandri, G.Bajocchi, M.Starnoni, G.De Santis, C.Salvarani, D.Giuggioli, Rheumatol. Ther. 2022, 9, 891.

[111] T.Dhlamini, N. N.Houreld, J. Diabetes Res. 2022, 2022, 3312840.

[112] M. H.Hwang, J. W.Lee, H. G.Son, J. Kim, H.Choi, Sci. Rep. 2020, 10, 9655.

[113] U. E.Reinhardt, Health Aff. 2003, 22, 27.

[114] A. E.Saltmarche, M. A. Naeser, K. F.Ho, M. R.Hamblin, L.Lim, Photomed. Laser Surg. 2017, 35, 432.

[115] C.Moro, N. E.Massri, N.Torres, D.Ratel, X.De Jaeger, C.Chabrol, F.Perraut, A.Bourgerette, M.Berger, S.Purushothuman, D. Johnstone, J.Stone, J.Mitrofanis, A. L.Benabid, J. Neurosurg. 2014, 120, 670.

[116] H.Chang, Y.Sheng, J.Liu, H. Yang, X.Pan, H.Liu, in IEEE Transactions on Cognitive and Developmental Systems, Vol. 15 (Ed: H. Tang), IEEE 2023, pp. 1085–1101.

[117] L. C.Gordon, K. L.Martin, N.Torres, A.-L.Benabid, J.Mitrofanis, J.Stone, C.Moro, D. M.Johnstone, Eur. J. Neurosci. 2023, 57, 1611.

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