Investigation on Klebsiella pneumoniae in the field of extracellular vesicles

Abstract

Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital-acquired pneumonia. The alarming rate of serious infections and associated mortality renders KP a significant public health threat. Extracellular vesicles (EVs) are pivotal in KP's physiological and pathological mechanisms, facilitating material and information transfer and mediating interactions between the bacteria and the host. The critical role of EVs enhances our understanding of KP pathophysiology, disease progression, and strategies for infection control. This review emphasizes the mechanics of KP's antibiotic resistance and the instrumental role of EVs in the bacterium-host interplay, proposing EVs as a promising research focus for advancing KP diagnosis, therapy, and prevention.

Keywords

antibiotic resistance / extracellular vesicles / Klebsiella pneumoniae / pneumonia / vaccines / virulence

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