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Bottom-up DNA nanostructure-based paper as point-of-care diagnostic: From method to device
Xueping Gao, Liu Feng, Ruijia Deng, Binpan Wang, Yuan He, Ligai Zhang, Dan Luo, Ming Chen, Kai Chang
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Bottom-up DNA nanostructure-based paper as point-of-care diagnostic: From method to device
Paper-based devices have attracted considerable attention in point-of-care testing (POCT) due to their simple operation and portability. The performance of paper-based POC assays is further enhanced by coupling with functional nucleic acids (FNAs), which are able to selectively recognize and bind to targets, amplify and transduce signals. Several high-performance paper-based POC assays have been developed, resulting from the different spatial structures of the paper-based device and detection strategies using different FNAs. In this review, we first introduce FNAs and paper-based devices, including their concepts, classifications and advances. The following section focuses on the application of these FNAs in POC assays using paperbased devices, taking into account their spatial one-, two- and three-dimensional structures. Finally, the challenges and perspectives of the application of FNAs in paper-based POCT are discussed.
DNA nanostructure / functional nucleic acid / paper-based devices / POCT / three dimensions
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