Autoimmune Adverse Events Following Immunization

Abstract

Adverse events (AEs) following immunization can include autoimmune AEs for some vaccines and combinations. This study retrospectively examines autoimmune AEs to detect safety signals for vaccines and concomitantly administered vaccines in the Vaccine Adverse Event Reporting System (VAERS) database. This study focuses on which vaccines were administered or coadministered for retrospective analysis of analyzed autoimmune AEs. Observed results include multiple autoimmune AE safety signals: human papillomavirus (HPV) Cervarix, HPV Gardasil, hepatitis (Hep) A + Hep B (Twinrix), Lyme disease (LYMErix), coadministered COVID-19 Moderna + Pfizer-BioNTech, Hep B (Engerix-B), and others. Identified arthritis AE safety signals include Lyme disease (LYMErix), rubella (Meruvax II), HPV (Cervarix), Anthrax (Biothrax) + Smallpox (Dryvax), and more. Coadministered DTaP + HepB + IPV (Pediarix) + Hib (Pedvaxhib) + Pneumococcal (Prevnar13) + Rotavirus (Rotarix) may be exhibiting synergy AE rate for eczema AEs. Thirty five influenza vaccines were observed with Guillain-Barré syndrome (GBS) AE safety signals, plus additional safety signals for multiple other vaccines. influenza (H1N1 monovalent) (GSK) exhibits a very high rate for narcolepsy AEs.

Keywords

Autoimmune / Adverse events / Arthritis / Complex regional pain syndrome / Guillain-Barré syndrome / Henoch Schonlein purpura / Postural orthostatic tachycardia syndrome / Systemic lupus erythematosus

Supplementary Materials

The following supporting information can be found at https://www.sciepublish.com/article/pii/627, Table S1: arthritis; Table S2: autoimmune thyroiditis; Table S3: chronic fatigue; Table S4: crps; Table S5: diabetes mellitus; Table S6: eczema; Table S7: encephalitis autoimmune; Table S8: Guillain Barre; Table S9: Henoch Schonlein; Table S10: immune thrombocytopenia; Table S11: narcolepsy; Table S12: neutropenia; Table S13: polymyalgia rheumatica; Table S14: pots; Table S15: psoriasis; Table S16: Raynaud; Table S17: restless legs; Table S18: Rheumatoid arthritis; Table S19: systemic lupus; Table S20 vasculitis.

Author Contributions

D.O.R.: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. The author has read and approved the submitted version.

Ethics Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data available at Ricke, Darrell, 2025, “Autoimmune Adverse Events Following Immunization”, https://doi.org/10.7910/DVN/RE23RJ, Harvard Dataverse, V2.

Funding

This research received no external funding.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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