Biology of tooth replacement in amniotes

Abstract

Researchers in Canada have explained the current theories on different tooth replacement patterns in vertebrate species. Like other vertebrates, the teeth we develop early in life are merely a ‘starter set’ that will ultimately be replaced. Mammals typically only undergo one round of replacement, while many fish and reptiles experience lifelong tooth replacement. Yet, the basis for this difference is not fully understood. In their review, John Whitlock and Joy Richman of the University of British Columbia, also present data suggesting that mammals may lose the dental lamina where tooth-forming stem cells reside, or fail to form the ‘successional lamina’ that contributes to later rounds of replacement in reptiles. The authors also explain mechanisms by which patterns of tooth renewal are established within the jaw, and recommend further study in reptile and mouse models.

Keywords

dental lamina / growth factor signalling / mammal / epithelial stem cells diphyodonty / polyphyodonty / reptile / successional lamina / tooth replacement / Zahnreihen, zone of inhibition

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