The research progress on periodontitis by the National Natural Science Foundation of China

Liang Xie , Qian Chen , Hao Xu , Cui Li , Jiayu Lu , Yuangui Zhu

International Journal of Oral Science ›› 2025, Vol. 17 ›› Issue (1) : 44

PDF
International Journal of Oral Science ›› 2025, Vol. 17 ›› Issue (1) : 44 DOI: 10.1038/s41368-025-00371-x
Review Article

The research progress on periodontitis by the National Natural Science Foundation of China

Author information +
History +
PDF

Abstract

Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research funding institution in China, the National Natural Science Foundation of China (NSFC) has played a pivotal role in driving the progress of periodontal science by supporting research on periodontitis. This article provides a comprehensive review of the research and development progress related to periodontitis in China from 2014 to 2023, highlighting the significant contributions of the NSFC to this field. We have summarized the detailed funding information from the NSFC, including the number of applicant codes, funded programs and the distribution of funded scholars. These data illustrate the efforts of the NSFC in cultivating young scientists and building research groups to address key challenges in national scientific research. This study offers an overview of the current hot topics, recent breakthroughs and future research prospects related to periodontitis in China.

Cite this article

Download citation ▾
Liang Xie, Qian Chen, Hao Xu, Cui Li, Jiayu Lu, Yuangui Zhu. The research progress on periodontitis by the National Natural Science Foundation of China. International Journal of Oral Science, 2025, 17(1): 44 DOI:10.1038/s41368-025-00371-x

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

MeyleJ, ChappleI. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000, 2015, 69: 7-17.

[2]

BartoldPM. Oral health and systemic health - the great disconnect. Aust. Dent. J., 2012, 57: 403.

[3]

CullinanMP, SeymourGJ. Periodontal disease and systemic illness: will the evidence ever be enough?. Periodontol 2000, 2013, 62: 271-286.

[4]

ChenMX, ZhongYJ, DongQQ, WongHM, WenYF. Global, regional, and national burden of severe periodontitis, 1990–2019: An analysis of the Global Burden of Disease Study 2019. J. Clin. Periodontol., 2021, 48: 1165-1188.

[5]

JiaoJ, et al. . The prevalence and severity of periodontal disease in Mainland China: Data from the Fourth National Oral Health Survey (2015–2016). J. Clin. Periodontol., 2021, 48: 168-179.

[6]

YuYM, et al. . Situational analysis of periodontal disease burden for adults in China from 1990 to 2019 and its incidence trend prediction. Zhonghua Kou Qiang Yi Xue Za Zhi, 2023, 58: 1265-1272

[7]

EkePI, BorgnakkeWS, GencoRJ. Recent epidemiologic trends in periodontitis in the USA. Periodontol 2000, 2020, 82: 257-267.

[8]

Antunes, A. et al. Geographical Distribution of Periodontitis Risk and Prevalence in Portugal Using Multivariable Data Mining and Modeling. Int. J. Environ. Res. Public Health. 19, 13634 (2022).

[9]

Könönen, E., Gursoy, M. & Gursoy, U. K. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. J. Clin. Med. 8, 1135 (2019).

[10]

GuoJ, et al. . Status of Tooth Loss and Denture Restoration in Chinese Adult Population: Findings from the 4th National Oral Health Survey. Chin. J. Dent. Res., 2018, 21: 249-257

[11]

KassebaumNJ, et al. . Global burden of untreated caries: a systematic review and metaregression. J. Dent. Res., 2015, 94: 650-658.

[12]

CatundaRQ, LevinL, KornerupI, GibsonMP. Prevalence of Periodontitis in Young Populations: A Systematic Review. Oral. Health Prev. Dent., 2019, 17: 195-202

[13]

BillingsM, et al. . Age-dependent distribution of periodontitis in two countries: Findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012. J. Periodontol., 2018, 89Suppl 1S140-s158

[14]

KönigJ, HoltfreterB, KocherT. Periodontal health in Europe: future trends based on treatment needs and the provision of periodontal services-position paper 1. Eur. J. Dent. Educ., 2010, 14Suppl 14-24.

[15]

Amuthavalli Thiyagarajan, J. et al. The UN Decade of healthy ageing: strengthening measurement for monitoring health and wellbeing of older people. Age Ageing. 51, afac147 (2022).

[16]

PatelJ, et al. . Oral health for healthy ageing. Lancet Healthy Longev., 2021, 2: e521-e527.

[17]

IaoS, et al. . Natural progression of periodontal diseases in Chinese villagers based on the 2018 classification. J. Periodontol., 2021, 92: 1232-1242.

[18]

NazirM, et al. . Global Prevalence of Periodontal Disease and Lack of Its Surveillance. ScientificWorldJournal, 2020, 2020: 2146160.

[19]

WaltherC, et al. . Evidence from the Hamburg City Health Study - association between education and periodontitis. BMC Public Health, 2022, 22. 1662

[20]

DarbyI. Risk factors for periodontitis & peri-implantitis. Periodontol 2000, 2022, 90: 9-12.

[21]

KhajaviA, RadvarM, MoeintaghaviA. Socioeconomic determinants of periodontitis. Periodontol 2000, 2022, 90: 13-44.

[22]

BertoldiC, et al. . Risk factors and socioeconomic condition effects on periodontal and dental health: A pilot study among adults over fifty years of age. Eur. J. Dent., 2013, 7: 336-346.

[23]

Almerich-SillaJM, Almiñana-PastorPJ, Boronat-CataláM, Bellot-ArcísC, Montiel-CompanyJM. Socioeconomic factors and severity of periodontal disease in adults (35–44 years). A cross sectional study. J. Clin. Exp. Dent., 2017, 9: e988-e994

[24]

KickbuschI, AllenL, FranzC. The commercial determinants of health. Lancet Glob. Health, 2016, 4: e895-e896.

[25]

GoelK, SharmaS, BaralDD, AgrawalSK. Current status of periodontitis and its association with tobacco use amongst adult population of Sunsari district, in Nepal. BMC Oral. Health, 2021, 21. 66

[26]

AlwithananiN. Periodontal Disease and Smoking: Systematic Review. J. Pharm. Bioallied Sci., 2023, 15: S64-s71.

[27]

LöeH. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care, 1993, 16: 329-334.

[28]

GrazianiF, GennaiS, SoliniA, PetriniM. A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review. J. Clin. Periodontol., 2018, 45: 167-187.

[29]

WuCZ, et al. . Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral. Health, 2020, 20. 204

[30]

FernandesJK, et al. . Periodontal disease status in gullah african americans with type 2 diabetes living in South Carolina. J. Periodontol., 2009, 80: 1062-1068.

[31]

SenS, et al. . Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke. Stroke, 2018, 49: 355-362.

[32]

RydénL, et al. . Periodontitis Increases the Risk of a First Myocardial Infarction: A Report From the PAROKRANK Study. Circulation, 2016, 133: 576-583.

[33]

GaoW, et al. . Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial. J. Periodontal Res, 2020, 55: 354-362.

[34]

Wu, Y. et al. Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population-based study. J. Clin. Periodontol. 51, 441–451 (2023).

[35]

CuiX, et al. . The association of aldehyde exposure with the risk of periodontitis: NHANES 2013–2014. Clin. Oral. Investig., 2023, 28: 29.

[36]

XiaoL, KarapenK, DongS, YangH, ZhangX. Epidemiology of periodontal disease in adolescents in mainland China, 1983–2020: a systematic review and meta-analysis. Ann. Palliat. Med, 2021, 10: 45-60.

[37]

ZhangT, et al. . Retrospective summary analysis on the results of oral health epidemiological investigations in China. J. Oral. Biol. Craniofac Res, 2022, 12: 809-817.

[38]

LiY, XieW, XiaoW, DouD. Progress in osteoarthritis research by the National Natural Science Foundation of China. Bone Res, 2022, 10: 41.

[39]

JiangC, ChenQ, XieM. Smoking increases the risk of infectious diseases: A narrative review. Tob. Induc. Dis., 2020, 18. 60

[40]

KongLZ. China’s Medium-to-Long Term Plan for the Prevention and Treatment of Chronic Diseases (2017–2025) under the Healthy China Initiative. Chronic Dis. Transl. Med., 2017, 3: 135-137

[41]

FangEF, et al. . A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev., 2020, 64: 101174.

[42]

ChenB, et al. . [Comparison of subgingival microbial profile of aggressive periodontitis, chronic periodontitis and periodontally healthy individuals]. Zhonghua Kou Qiang Yi Xue Za Zhi, 2020, 55: 466-474

[43]

LiuG, et al. . Shift in the subgingival microbiome following scaling and root planing in generalized aggressive periodontitis. J. Clin. Periodontol., 2018, 45: 440-452.

[44]

LiX, et al. . The recovery of the microbial community after plaque removal depends on periodontal health status. NPJ Biofilms Microbiomes, 2023, 9. 75

[45]

HuangPQ, JiaXY, ZhaoL, ZhouXD, XuX. Research Updates: Relationship between Gingival Epithelial Intercellular Junctions and Periodontal Pathogenic Bacteria. Sichuan Da Xue Xue Bao Yi Xue Ban., 2022, 53: 214-219

[46]

ZhangJ, et al. . Interactions of periodontal pathogens with platelets in the gingival crevicular fluid of patients with periodontitis. J. Clin. Periodontol., 2022, 49: 922-931.

[47]

SongJ, et al. . The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis. Adv. Sci. (Weinh.), 2023, 10e2303207

[48]

LuR, MengH, GaoX, XuL, FengX. Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis. J. Periodontal Res, 2014, 49: 574-583.

[49]

WuHZ, ZhangX, ChengXG, YuQ. Saliva microbiota and metabolite in individuals with caries or periodontitis. Zhonghua Kou Qiang Yi Xue Za Zhi, 2023, 58: 131-142

[50]

QiaoS, et al. . Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo. Oral. Dis., 2023, 29: 3571-3582.

[51]

ShenZ, et al. . The spatial transcriptomic landscape of human gingiva in health and periodontitis. Sci. China Life Sci., 2024, 67: 720-732.

[52]

JiangW, et al. . CCL2 is a key regulator and therapeutic target for periodontitis. J. Clin. Periodontol., 2023, 50: 1644-1657.

[53]

LiJ, et al. . Effect of type 2 diabetes mellitus and periodontitis on the Th1/Th2 and Th17/Treg paradigm. Am. J. Dent., 2022, 35: 55-60

[54]

BiCS, et al. . The relationship between T-helper cell polarization and the RANKL/OPG ratio in gingival tissues from chronic periodontitis patients. Clin. Exp. Dent. Res, 2019, 5: 377-388.

[55]

ZhouT, et al. . The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations. Front Cell Infect. Microbiol, 2023, 13: 1132420.

[56]

ShenDN, WuYF, ZhaoL. [Roles of periodontal pathogens in the pathogenesis of atherosclerosis]. Zhonghua Kou Qiang Yi Xue Za Zhi, 2021, 56: 584-590

[57]

DominySS, et al. . Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv., 2019, 5. eaau3333

[58]

LiuJ, et al. . Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. Bioact. Mater., 2024, 33: 85-99

[59]

XiY, WangY, GaoJ, XiaoY, DuJ. Dual Corona Vesicles with Intrinsic Antibacterial and Enhanced Antibiotic Delivery Capabilities for Effective Treatment of Biofilm-Induced Periodontitis. ACS Nano, 2019, 13: 13645-13657.

[60]

HuH, et al. . Integrated microbiome and metabolomics revealed the protective effect of baicalin on alveolar bone inflammatory resorption in aging. Phytomedicine, 2024, 124: 155233.

[61]

RenM, et al. . Baicalein inhibits inflammatory response and promotes osteogenic activity in periodontal ligament cells challenged with lipopolysaccharides. BMC Complement Med. Ther., 2021, 21: 43.

[62]

ZhuC, et al. . The therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway. J. Periodontal. Res., 2020, 55: 381-391.

[63]

XiaoCJ, YuXJ, XieJL, LiuS, LiS. Protective effect and related mechanisms of curcumin in rat experimental periodontitis. Head. Face Med., 2018, 14: 12.

[64]

ShiW, et al. . Curcumin promotes osteogenic differentiation of human periodontal ligament stem cells by inducting EGR1 expression. Arch. Oral. Biol., 2021, 121: 104958.

[65]

ZhaoY, et al. . Design, synthesis, and evaluation of mono-carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis. J. Periodontal. Res., 2021, 56: 656-666.

[66]

DengJ, et al. . A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis. J. Inflamm. Res., 2021, 14: 5337-5347.

[67]

XuS, et al. . Alleviate Periodontitis and Its Comorbidity Hypertension using a Nanoparticle-Embedded Functional Hydrogel System. Adv. Health. Mater., 2023, 12. e2203337

[68]

CaiY, et al. . Green tea epigallocatechin-3-gallate alleviates Porphyromonas gingivalis-induced periodontitis in mice. Int. Immunopharmacol., 2015, 29: 839-845.

[69]

ZengJ, WangY, YuanQ, LuanQ. The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial. Trials, 2022, 23. 368

[70]

WangY, ZengJ, YuanQ, LuanQ. Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial. BMC Oral. Health, 2021, 21. 79

[71]

XuanY, et al. . Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway. Microbes Infect., 2023, 25: 105177.

[72]

LiY, et al. . Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes. Bioact. Mater., 2022, 18: 213-227

[73]

GuoJ, et al. . MiRNA-218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9. Cell Microbiol., 2019, 21. e12979

[74]

LiX, et al. . Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function. Int J. Oral. Sci., 2023, 15: 51.

[75]

YinY, et al. . Gold nanoparticles targeting the autophagy-lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: From mechanism to therapy. Biomaterials, 2022, 288: 121743.

[76]

WeiW, AnY, AnY, FeiD, WangQ. Activation of autophagy in periodontal ligament mesenchymal stem cells promotes angiogenesis in periodontitis. J. Periodontol., 2018, 89: 718-727.

[77]

ZhouYK, YangRL, LiuXM. Hydrogen Sulphide Alleviates Senescence of Human Periodontal Ligament Stem Cells by TRPV4 Channel Mediated Calcium Flux. Chin. J. Dent. Res, 2023, 26: 19-27

[78]

ChenY, et al. . Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis. Theranostics, 2022, 12: 1074-1096.

[79]

WangC, et al. . CD301b(+) macrophage: the new booster for activating bone regeneration in periodontitis treatment. Int J. Oral. Sci., 2023, 15: 19.

[80]

DuJ, et al. . BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism. Nat. Commun., 2023, 14. 1413

[81]

Li, Y. et al. Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4. Nutrients. 15, 2115 (2023).

[82]

HuangX, et al. . The roles of osteocytes in alveolar bone destruction in periodontitis. J. Transl. Med., 2020, 18. 479

[83]

ZhangZ, DengM, HaoM, TangJ. Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms. J. Leukoc. Biol., 2021, 110: 565-576.

[84]

BaoL, et al. . Dysfunction of MiR-148a-NRP1 Functional Axis Suppresses Osteogenic Differentiation of Periodontal Ligament Stem Cells Under Inflammatory Microenvironment. Cell Reprogram, 2019, 21: 314-322.

[85]

YuanZ, et al. . Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress. Int J. Oral. Sci., 2024, 16: 38.

[86]

LiH, et al. . Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response. Stem Cell Res. Ther., 2020, 11: 215.

[87]

MenY, et al. . Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force. Dev. Cell, 2020, 54: 639-654.e636.

[88]

LeiF, et al. . Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes. Acta Biomater., 2022, 141: 333-343.

[89]

XuJ, et al. . Periodontal Ligament Stem Cell-Derived Extracellular Vesicles Enhance Tension-Induced Osteogenesis. ACS Biomater. Sci. Eng., 2023, 9: 388-398.

[90]

XiaY, et al. . Human bone marrow mesenchymal stem cell-derived extracellular vesicles restore Th17/Treg homeostasis in periodontitis via miR-1246. Faseb j., 2023, 37. e23226

[91]

LiG, et al. . SFRP2 promotes stem cells from apical papilla-mediated periodontal tissue regeneration in miniature pig. J. Oral. Rehabil., 2020, 47Suppl 112-18.

[92]

ChengX, et al. . Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis. J. Neuroinflammation, 2023, 20. 55

[93]

ShenZ, et al. . Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3n(high) astrocytes in the hippocampus. Innov. (Camb.), 2024, 5: 100547

[94]

WuL, et al. . Alterations and Correlations of Gut Microbiota and Fecal Metabolome Characteristics in Experimental Periodontitis Rats. Front. Microbiol., 2022, 13: 865191.

[95]

LiL, et al. . Periodontitis may impair the homeostasis of systemic bone through regulation of gut microbiota in ApoE(-/-) mice. J. Clin. Periodontol., 2022, 49: 1304-1319.

[96]

ChanWC, et al. . Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the nuclear factor-κB pathway. Oral. Dis., 2023, 29: 1802-1811.

[97]

ZhangT, et al. . Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment. J. Periodontal. Res., 2023, 58: 70-82.

[98]

WangD, et al. . Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross-sectional and prospective cohort studies based on UK Biobank. J. Clin. Periodontol., 2024, 51: 97-107.

[99]

SuY, et al. . Periodontitis as a promoting factor of T2D: current evidence and mechanisms. Int J. Oral. Sci., 2023, 15: 25.

[100]

LiB, et al. . SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation resolution of diabetic periodontitis. Theranostics, 2023, 13: 231-249.

[101]

PapapanouPN, et al. . Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol., 2018, 45Suppl 20S162-s170

[102]

ShaoJL, YuY, LyuCX, GeSH. Introduction and interpretation of the European Federation of Periodontology S3 level clinical practice guideline for treatment of periodontitis. Zhonghua Kou Qiang Yi Xue Za Zhi, 2022, 57: 1202-1208

[103]

Wang, J. et al. Manufacture and Quality Control of Human Umbilical Cord-Derived Mesenchymal Stem Cell Sheets for Clinical Use. Cells. 11, 2732 (2022).

[104]

LiL, XuY. Application and prospect of electrospinning in functional periodontal tissue regeneration. Zhonghua Kou Qiang Yi Xue Za Zhi, 2023, 58: 636-641

[105]

NiC, et al. . Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment. Biomaterials, 2019, 206: 115-132.

[106]

QianY, et al. . Triple PLGA/PCL Scaffold Modification Including Silver Impregnation, Collagen Coating, and Electrospinning Significantly Improve Biocompatibility, Antimicrobial, and Osteogenic Properties for Orofacial Tissue Regeneration. ACS Appl. Mater. Interfaces, 2019, 11: 37381-37396.

[107]

XieY, et al. . Cascade and Ultrafast Artificial Antioxidases Alleviate Inflammation and Bone Resorption in Periodontitis. ACS Nano, 2023, 17: 15097-15112.

[108]

Lin, Z., Nica, C., Sculean, A. & Asparuhova, M. B. Enhanced Wound Healing Potential of Primary Human Oral Fibroblasts and Periodontal Ligament Cells Cultured on Four Different Porcine-Derived Collagen Matrices. Materials (Basel). 13, 3819 (2020).

[109]

DongJC, LiaoY, ChenHW, SongZC. Outcome of lingual gingival recession treated with the tunnel technique plus subepithelial connective tissue graft technique: a case report. Zhonghua Kou Qiang Yi Xue Za Zhi, 2022, 57: 1243-1246

[110]

LiuS, et al. . Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates In Situ Periodontal Tissue Regeneration. ACS Appl. Mater. Interfaces, 2021, 13: 36880-36893.

[111]

SowadaJ, et al. . Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin. Arch. Toxicol., 2017, 91: 2331-2341.

[112]

BullonP, et al. . Metabolic syndrome and periodontitis: is oxidative stress a common link?. J. Dent. Res., 2009, 88: 503-518.

[113]

RitchieCS. Mechanistic links between type 2 diabetes and periodontitis. J. Dent., 2009, 37: S578-S579.

[114]

PatilVS, PatilVP, GokhaleN, AcharyaA, KangokarP. Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury. J. Clin. Diagn. Res., 2016, 10: Bc12-Bc16

[115]

SczepanikFSC, et al. . Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way. Periodontol 2000, 2020, 84: 45-68.

[116]

Czesnikiewicz-GuzikM, et al. . Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur. Heart J., 2019, 40: 3459-3470.

[117]

EasterQT, et al. . Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis. Nat. Commun., 2024, 15. 5016

[118]

DursunE, et al. . Oxidative Stress and Periodontal Disease in Obesity. Med. (Baltim.), 2016, 95. e3136

[119]

KhosraviR, et al. . Tumor necrosis factor- α and interleukin-6: potential interorgan inflammatory mediators contributing to destructive periodontal disease in obesity or metabolic syndrome. Mediators Inflamm., 2013, 2013: 728987.

[120]

GencoRJ, GrossiSG, HoA, NishimuraF, MurayamaY. A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J. Periodontol., 2005, 76: 2075-2084.

[121]

NocitiFHJr, CasatiMZ, DuartePM. Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontol 2000, 2015, 67: 187-210.

[122]

DietrichT, et al. . Smoking, Smoking Cessation, and Risk of Tooth Loss: The EPIC-Potsdam Study. J. Dent. Res., 2015, 94: 1369-1375.

[123]

AkinkugbeAA, et al. . Environmental tobacco smoke exposure and periodontitis prevalence among nonsmokers in the hispanic community Health Study/Study of Latinos. Community Dent. Oral. Epidemiol., 2017, 45: 168-177.

[124]

Almerich-SillaJM, et al. . Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria. Dis. Markers, 2015, 2015. 653537

[125]

BaňasováL, et al. . Salivary DNA and markers of oxidative stress in patients with chronic periodontitis. Clin. Oral. Investig., 2015, 19: 201-207.

[126]

AboodiGM, GoldbergMB, GlogauerM. Refractory periodontitis population characterized by a hyperactive oral neutrophil phenotype. J. Periodontol., 2011, 82: 726-733.

[127]

NguyenT, BrodyH, RadaicA, KapilaY. Probiotics for periodontal health-Current molecular findings. Periodontol 2000, 2021, 87: 254-267.

[128]

Mulhall, H. et al. Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis. Infect. Immun. 89, e00500–20 (2020).

[129]

RenZ, et al. . Association between probiotic consumption and periodontitis: Evidence from NHANES 2009–2014. J. Clin. Periodontol., 2023, 50: 1476-1486.

[130]

XuH, et al. . ScRNA-seq links dental fibroblasts heterogeneity with mechanoresponsiveness. J. Periodontal. Res., 2023, 58: 800-812.

[131]

Cai, X. Y. et al. Inflammation-triggered Gli1(+) stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology. Cell. Mol. Immunol. 22, 371–389 (2025).

[132]

WangZ, et al. . Tim4 deficiency reduces CD301b(+) macrophage and aggravates periodontitis bone loss. Int J. Oral. Sci., 2024, 16: 20.

[133]

GigerML. Machine Learning in Medical Imaging. J. Am. Coll. Radio., 2018, 15: 512-520.

[134]

EstevaA, et al. . A guide to deep learning in healthcare. Nat. Med, 2019, 25: 24-29.

[135]

AndradeKM, SilvaBPM, de OliveiraLR, CuryPR. Automatic dental biofilm detection based on deep learning. J. Clin. Periodontol., 2023, 50: 571-581.

[136]

LeeCT, et al. . Use of the deep learning approach to measure alveolar bone level. J. Clin. Periodontol., 2022, 49: 260-269.

[137]

SuS, et al. . Automatic tooth periodontal ligament segmentation of cone beam computed tomography based on instance segmentation network. Heliyon, 2024, 10. e24097

[138]

Jepsen, S. et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol.89(Suppl 1), S237–S248 (2018).

[139]

OuchiT, NakagawaT. Mesenchymal stem cell-based tissue regeneration therapies for periodontitis. Regen. Ther., 2020, 14: 72-78.

[140]

Moreno SanchoF, et al. . Cell-Based Therapies for Alveolar Bone and Periodontal Regeneration: Concise Review. Stem Cells Transl. Med, 2019, 8: 1286-1295.

[141]

Park, J. et al. Enhanced Osteogenic Differentiation of Periodontal Ligament Stem Cells Using a Graphene Oxide-Coated Poly(ε-caprolactone) Scaffold. Polymers (Basel). 13, 797 (2021).

[142]

ZhangT, et al. . Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis. Genes Dis., 2023, 10: 1613-1625.

[143]

SuiBD, et al. . Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis. Physiol. Rev., 2023, 103: 1899-1964.

[144]

DengDK, et al. . Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential. J. Nanobiotechnology, 2022, 20. 545

[145]

ChenL, ZhuS, GuoS, TianW. Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration. Stem Cell Res Ther., 2023, 14: 26.

[146]

FuX, JinL, MaP, FanZ, WangS. Allogeneic stem cells from deciduous teeth in treatment for periodontitis in miniature swine. J. Periodontol., 2014, 85: 845-851.

[147]

CaoY, et al. . Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine. Stem Cell Res Ther., 2015, 6: 249.

[148]

HuJ, et al. . Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice. Stem Cell Res Ther., 2016, 7: 130.

[149]

Hasturk, H., Hajishengallis, G., Lambris, J. D., Mastellos, D. C. & Yancopoulou, D. Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation. J. Clin. Investig. 131, e152973 (2021).

[150]

KajikawaT, et al. . Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol. Ther. Methods Clin. Dev., 2017, 6: 207-215.

[151]

MaekawaT, et al. . Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol., 2016, 43: 238-249.

[152]

AnJY, et al. . Rapamycin treatment attenuates age-associated periodontitis in mice. Geroscience, 2017, 39: 457-463.

RIGHTS & PERMISSIONS

The Author(s)

AI Summary AI Mindmap
PDF

196

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/