Magnesium promotes vascularization and osseointegration in diabetic states

doi:10.1038/s41368-023-00271-y

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International Journal of Oral Science ›› 2024, Vol. 16 ›› Issue (0) : 10. DOI: 10.1038/s41368-023-00271-y

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Magnesium promotes vascularization and osseointegration in diabetic states

Linfeng Liu¹, Feiyu Wang¹, Wei Song¹, Danting Zhang¹, Weimin Lin¹, Qi Yin¹, Qian Wang¹, Hanwen Li¹, Quan Yuan^1,2, Shiwen Zhang^1,2

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Abstract

Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg²⁺ promotes angiogenesis and osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants successfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg²⁺ promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data suggested that Mg²⁺ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.

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Linfeng Liu, Feiyu Wang, Wei Song, Danting Zhang, Weimin Lin, Qi Yin, Qian Wang, Hanwen Li, Quan Yuan, …Shiwen Zhang. Magnesium promotes vascularization and osseointegration in diabetic states. International Journal of Oral Science, 2024, 16(0): 10 https://doi.org/10.1038/s41368-023-00271-y

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