Gene therapy targeting a pain receptor in nerve cells carrying signals from the jaw could be an effective treatment for the pain associated with orthodontic treatment. Pain triggered by the movement of teeth is a common reason why patients terminate orthodontic treatment early. Previous studies have suggested that tooth movement is associated with an increase in the expression of transient receptor potential vanilloid 1 (TRPV1), a receptor which is activated by various physical and chemical stimuli, triggering pain. In this study, Wenli Lai at Sichuan University and colleagues confirm that TRPV1 expression increases in response to orthodontic forces which coincide with tooth movement pain in rats. They also show that a lentivirus vector can be used to deliver a small interfering RNA molecule that blocks the expression of TRPV1, alleviating pain.
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Funding
National Natural Science Foundation of China (National Science Foundation of China)(81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884, 81571004, 81500884)
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