Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice

Abstract

Swabbing the mouths of germ-free mice with human saliva can provide an effective mouse model for studying the roles of human oral bacteria in mouth and gut diseases. The human oral microbiota-associated (HOMA) mice were developed by Lei Cheng of Sichuan University and colleagues in China and bred alone for 35 days. A significant proportion (85%) of the types of bacteria present in the human donors’ saliva successfully established themselves in the germ-free mice and colonised various parts of their guts. When the HOMA mice were co-bred with other types of mouse models, digestive tract bacteria transferred to them, preventing oral bacteria from significantly colonising the gut. The researchers conclude that a HOMA model was successfully established and could help overcome current limitations in investigations related to human oral bacteria and disease.

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Funding

National Natural Science Foundation of China (National Science Foundation of China)(81372889)

Youth Grant of the Science and Technology Department of Sichuan Province, China 2017JQ0028

National Key Research and Development Program of China 2016YFC1102700

National Natural Science Foundation of China grant 81600858

National Basic Research Program of China 973 Program 2013CB532406