Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc

Abstract

Chronic inflammation damages the collagen disk that cushions the temporomandibular joint (TMJ) of the jaw, contributing to jaw disorders. Although chronic inflammation is known to harm collagen, its effects on TMJ disks were unclear. Xue-Dong Wang and Yan-Heng Zhou and coworkers at the Peking University School and Hospital of Stomatology in Beijing used advanced imaging technologies to investigate how inflammation affects TMJ collagen in rats. In TMJ disks, collagen is composed of long, intertwined threads called fibrils. Inflammation damaged the collagen’s chemical structure, preventing correct winding, and resulting in oversized and unevenly arranged fibrils. The TMJ disks were overly porous, with poor elasticity. The researchers hypothesize that these changes thicken and deform TMJ disks, leading to disk displacement and jaw disorders. Further studies are needed to determine whether anti-inflammatory treatments can protect TMJ collagen.

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Funding

National Natural Science Foundation of China (National Science Foundation of China)(81671015, 81571815, 81470717)

Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation)(Z171100001017128)