The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein

Abstract

Along with phosphophoryn (PP), dental sialoprotein (DSP) is the dominant non-collagen protein in dentin, and in vitro studies have demonstrated that DSP is involved in inducing the differentiation of dental pulp cells into odontoblast-like cells, which form dentin. PP is known to be involved in the mineralization of dentin, but the functional significance of DSP had been controversial. Helena Ritchie of the University of Michigan School of Dentistry conducted a review of studies investigating the derivation, function and distribution of PP and DSP. It was originally thought that PP and DSP were synthesized independently; later, it became evident that they derive from a single DSP-PP gene. Wider DSP-PP distribution in various tissues, including kidney and salivary glands, and DSP or PP expression in non-mineralized tissues suggest that the proteins may have functions other than mineralization.

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