Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis

Abstract

A Chinese herbal supplement could treat an inflammatory autoimmune disease of the tissues surrounding the teeth. Zhipeng Fan and colleagues at Capital Medical University in Beijing, China found reduced inflammation and improved tissue regeneration in induced periodontitis in miniature pigs, three months following local injections with the Chinese herbal extract icariin. Periodontitis is an overactive immune response to bacterial invasion in the gums, leading to the breakdown of supportive tissue and bone, and potential tooth loss. Clinical assessment, CT scans and microscopic examination showed icariin injections promoted gum and bone regeneration, possibly by stimulating local stem cells. It also reduced signs of inflammation, including significantly decreasing the expression of IL-1β, an immune response mediator. Further studies are needed to confirm icariin’s mode of action and optimal dosage for potential clinical use.

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