RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement

Abstract

Cells and tissues have been identified that produce a signaling molecule essential for bone remodeling in orthodontic patients. Directional mechanical force, when applied to teeth, instigates changes to remodel the bone around the tooth. Researchers from the University of Pennsylvania School of Dental Medicine in Philadelphia, led by Dana Graves, genetically altered mice to remove ‘RANKL’, a protein thought to be a mediator in the breakdown of bone. The team found that the immune cells responsible for producing RANKL are primarily found in the tissue connecting tooth roots to the ridges of bone containing the tooth sockets and the protective cells that line the bones. Removing RANKL impaired the ability of the teeth to move in response to external directional force. This study provides insights into the relationship between RANKL production and orthodontic tooth movement.

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