Orthodontic tooth separation activates the hypothalamic area in the human brain
Yoshiko Ariji , Hisataka Kondo , Ken Miyazawa , Masako Tabuchi , Syuji Koyama , Yoshitaka Kise , Akifumi Togari , Shigemi Gotoh , Eiichiro Ariji
International Journal of Oral Science ›› 2018, Vol. 10 ›› Issue (2) : 8
Orthodontic tooth separation activates the hypothalamic area in the human brain
Identifying the nerve pathways involved in tooth movement could lead to better targets for pain relief. Non-steroidal anti-inflammatory drugs cannot be used to relieve orthodontic pain because they impair the processes involved in tooth movement. Yoshiko Ariji of Japan’s Aichi-Gakuin University School of Dentistry, Nagoya, and colleagues used functional MRI scans of ten healthy adult volunteers to identify the parts of the brain that become active when separators are briefly inserted between pre-molar teeth. They found separator insertion led to a significant rise in the activity of the hypothalamus and the part of the brain’s cerebral cortex associated with touch and proprioception. Together with the results of previous studies in mice, the results suggest a nerve pathway that could be targeted to alleviate pain from orthodontic procedures without negatively impacting tooth movement.
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