Doxycycline induces bone repair and changes in Wnt signalling

Abstract

An antibiotic commonly used to treat bacterial infections helps promote healing in the jawbones of rats. Glauce Viana and colleagues from the Federal University of Ceará in Fortaleza, Brazil, extracted upper molar teeth from rats and then treated the animals with either the antibiotic drug doxycycline or a saline control. After seven days, the rats that received doxycycline had less inflammation in their tooth sockets than the controls, and after 14 days, more signs of successful wound closure. Looking closely at the cells in the repaired bone in the antibiotic-treated rats, the researchers saw more bone-forming osteoblast cells, fewer bone-resorbing osteoclast cells and greater activity of a signaling pathway known to improve bone healing. The authors suggest the drug should now be tested in people suffering from periodontal disease.

Keywords

alveolar bone loss / bone diseases / bone repair / doxycycline / Dickkopf-1 / immunohistochemistry / Wnt-10b

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