Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

Abstract

Platelet-rich plasma (PRP) therapy offers potential for nerve regeneration, particularly peripheral nerve recovery around dental implants. Regeneration of nerve fibers and restoration of sensory feedback can present problems following dental implant placement. Owing to its safety and applicability, PRP therapy has shown promise in treating musculoskeletal injuries. Reinhilde Jacobs (University of Leuven, Belgium), Haiyang Yu (Sichuan University, China) and and coworkers reviewed basic research studies and preliminary clinical trials on the biological efficacy of PRP in peripheral nerve regeneration. The authors concluded that various growth factors released by PRP may indeed modify and promote sensory feedback around a dental implant. However, further research is necessary before using PRP with dental implants can be advocated as safe, effective treatment. Among the authors' recommendations for future studies are optimizing the clinical efficacy of growth factors within PRP.

Keywords

neural regeneration / osseoperception / peripheral nerve degeneration / peri-implant sensory feedback / platelet-rich plasma

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