Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis

Abstract

Different strains of pathogenic bacteria rely on distinct interactions to anchor themselves firmly into oral ‘biofilm’ communities. The microbe Fusobacterium nucleatum is a major component of these densely populated bacterial societies. This species is not harmful, but can mediate recruitment of disease-causing Porphyromonas gingivalis bacteria into biofilms. Renate Lux and colleagues at the University of California at Los Angeles have demonstrated that various strains of P. gingivalis apparently latch onto different proteins on the surface of F. nucleatum. Previous studiesidentified the protein Fap2 as a binding target for P. gingivalis, but Lux and colleagues found at least one strain that relies on a different protein and found evidence for other as yet unidentified protein ‘anchors’. Identifying the proteins recognized by the most virulent P. gingivalis strains could lead to therapeutics that selectively block these interactions.

Keywords

adhesin / biofilm / coaggregation / Fusobacterium nucleatum / Porphyromonas gingivalis

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