Phenotypic research on senile osteoporosis caused by SIRT6 deficiency

Abstract

Scientists in China have investigated a possible role for the enzyme SIRT-6 in age-related osteoporosis. Xuedong Zhou and co-workers at Sichuan University sought to clarify the mechanisms of senile osteoporosis, which affects women aged at least 65 years and men aged 70 or more. The mechanisms of the condition remain unclear, but previous research suggests a role for the SIRT-6 enzyme, which may regulate a number of genes involved in maintaining bone structure. Zhou’s team created mice in which the gene that codes for the SIRT-6 enzyme had been shut down. They observed significant effects on mouse bone and cartilage, confirming that SIRT-6 is an important regulator of bone metabolism. The researchers now hope to uncover more evidence for the proposed role for SIRT-6 in senile osteoporosis.

Keywords

ageing / osteoclastogenesis / osteogenesis / osteoporosis

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