Modification of tooth development by heat shock protein 60

Abstract

Increased levels of a protein produced in response to stress cause abnormal tooth development. Similar ‘heat shock’ proteins, including Hsp 25 and Hsp 27, have previously been implicated in the origin and formation of teeth, but no one had looked at Hsp 60. Tamás Papp from the University of Debrecen, Hungary, and colleagues examined the expression pattern of Hsp 60 in the lower incisors of mice. They found high levels of the protein in tooth germs, in layers inside the enamel organ called the stratum intermedium, ameloblasts and in cells of the outer dental pulp. The authors applied extra amounts of Hsp 60 to the teeth of embryonic mice and observed morphological defects in the precursor cells that eventually form teeth. The findings suggest that Hsp 60 could be involved in dental disease.

Keywords

enamel organ / heat shock protein 60 / inhibitor of κB kinase / morphology / mouse / tooth development

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