Characterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers

Abstract

Dental stem cells with the greatest potential for regenerating bone and cartilage can be identified by three proteins on the cell surface. Christine Hong and co-workers at the University of California Los Angeles investigated stem cells purified from the ligaments that attach teeth to the jaw bone. This tissue can be readily obtained from extracted teeth. It offers a convenient source of stem cells that have previously been shown to regenerate bone, the surface layer of tooth root, and the ligament itself. Hong’s team found that human stem cells obtained in this way vary significantly in their regenerative capacity and therefore therapeutic potential. They identified the combination of surface proteins that marks out the best cells for repairing bone and cartilage. This will assist the isolation of uniform preparations of these cells for regenerative therapy.

Keywords

cell surface markers / dental mesenchymal stem cells / periodontal ligament

References

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