The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands

Abstract

Collagen gel containing basic fibroblast growth factor could assist the regeneration of submandibular glands after damage during surgery. The slow healing of these large salivary glands, which lie beneath the floor of the mouth, causes difficulties with speaking, swallowing and digestion, and an increased susceptibility to oral infection. These problems can significantly impair a patient's quality of life. Fumitaka Kobayashi at Tokyo Dental College and co-workers explored the healing potential of basic fibroblast growth factor in collagen gel using rats that had been wounded to model surgical damage. They also monitored the proliferation and development of the specific types of cell involved in repairing the wounded tissue. Treating the wounds using collagen containing growth factor accelerated and improved healing to a greater extent than using collagen gel alone.

Keywords

animal model / basic fibroblast growth factor / collagen / immunohistochemistry / salivary gland / wound healing

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