A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine

Abstract

A new protein-repelling dental composite prevents bacterial attachment and plaque build-up while retaining its mechanical strength. Secondary tooth decay following tooth restoration is responsible for the replacement of almost half of all dental restorations within 10 years. An international team led by Hockin HK Xu at the University of Maryland now show that incorporating up to 3% 2-methacryloyloxyethyl phosphorylcholine (MPC) into a dental resin significantly repelled the deposit of salivary proteins that act as anchor points for bacterial attachment. After 48-h exposure to a solution that simulates the oral environment, the MPC resin had less bacterial coverage than controls, and its load-bearing capability was unaffected. MPC has already been incorporated successfully into several medical devices. This study suggests a promising new use in dental composites with the potential to prevent secondary tooth decay.

Keywords

caries inhibition / human saliva microcosm biofilm / mechanical property / protein repellent / resin composite

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