Lipopolysaccharide inhibits or accelerates biomedical titanium corrosion depending on environmental acidity

Abstract

Bacterial lipopolysaccharide (LPS) can accelerate or inhibit the corrosion of titanium implants depending on the acidity of the environment. These contrasting effects were demonstrated by Owen Addison and colleagues from Birmingham University, UK. Titanium and its alloys are used in biomedical implants and are generally resistant to corrosion under normal physiological conditions. Inflammation and bacterial activity can, however, modify the local environment in the biofilms around dental implants. The researchers therefore investigated the effects of LPS from bacterial cell walls on corrosion. At normal acidity levels corrosion increased in the presence of LPS, but in the more acidic conditions associated with inflammation corrosion was inhibited. Increased acidity in the absence of LPS increases corrosion. The effects of LPS may influence the long-term stability of many implants.

Keywords

corrosion / electrochemistry / inductively coupled plasma mass spectrometry / lipopolysaccharide / titanium

References

[1] Liu XY, Chu PK, Ding CX. Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mater Sci Eng R, 2004, 47(3/4): 49-121.

[2] Cadosch D, Chan E, Gautschi OP. Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening—current concepts. J Biomed Mater Res A, 2009, 91(4): 1252-1262.

[3] Mabilleau G, Bourdon S, Joly-Guillou ML. Influence of fluoride, hydrogen peroxide and lactic acid on the corrosion resistance of commercially pure titanium. Acta Biomater, 2006, 2(1): 121-129.

[4] Virtanen S, Curty C. Metastable and stable pitting corrosion of titanium in halide solutions. Corrosion, 2004, 60(7): 643-649.

[5] He XH, Noel JJ, Shoesmith DW. Temperature dependence of crevice corrosion initiation on titanium grade-2. J Electrochem Soc, 2002, 149(9): B440-B449.

[6] Yan L, Noel JJ, Shoesmith DW. Hydrogen absorption into Grade-2 titanium during crevice corrosion. Electrochim Acta, 2011, 56(4): 1810-1822.

[7] Thomas SR, Shukla D, Latham PD. Corrosion of cemented titanium femoral stems. J Bone Joint Surg Br, 2004, 86(7): 974-978.

[8] Hallam P, Haddad F, Cobb J. Pain in the well-fixed, aseptic titanium hip replacement. The role of corrosion. J Bone Joint Surg Br, 2004, 86(1): 27-30.

[9] Addison O, Davenport AJ, Newport RJ. Do ‘passive’ medical titanium surfaces deteriorate in service in the absence of wear. J R Soc Interface, 2012, 9(76): 3161-3164.

[10] Uo M, Asakura K, Yokoyama A. X-ray absorption fine structure (XAFS) analysis of titanium-implanted soft tissue. Dent Mater J, 2007, 26(2): 268-273.

[11] Sarmiento-González A, Encinar JR, Marchante-Gayón JM. Titanium levels in the organs and blood of rats with a titanium implant, in the absence of wear, as determined by double-focusing ICP-MS. Anal Bioanal Chem, 2009, 393(1): 335-343.

[12] Nuevo-Ordóñez Y, Montes-Bayón M, Blanco-González E. Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels. Anal Bioanal Chem, 2011, 401(9): 2747-2754.

[13] Flatebø RS, Johannessen AC, Grønningsaeter AG. Host response to titanium dental implant placement evaluated in a human oral model. J Periodontol, 2006, 77(7): 1201-1210.

[14] Cadosch D, Al-Mushaiqri MS, Gautschi OP. Biocorrosion and uptake of titanium by human osteoclasts. J Biomed Mater Res A, 2010, 95(4): 1004-1010.

[15] Baldwin L, Hunt JA. Host inflammatory response to NiCr, CoCr, and Ti in a soft tissue implantation model. J Biomed Mater Res A, 2006, 79(3): 574-581.

[16] Virtanen S, Milosev I, Gomez-Barrena E. Special modes of corrosion under physiological and simulated physiological conditions. Acta Biomater, 2008, 4(3): 468-476.

[17] Hanawa T. Metal ion release from metal implants. Mater Sci Eng C, 2004, 24(6/7/8): 745-752.

[18] Souza JC, Ponthiaux P, Henriques M. Corrosion behaviour of titanium in the presence of Streptococcus mutans. J Dent, 2013, 41(6): 528-534.

[19] Koike M, Fujii H. The corrosion resistance of pure titanium in organic acids. Biomaterials, 2001, 22(21): 2931-2936.

[20] Cheng X, Roscoe SG. Corrosion behavior of titanium in the presence of calcium phosphate and serum proteins. Biomaterials, 2005, 26(35): 7350-7356.

[21] Jackson DR, Omanovic S, Roscoe SG. Electrochemical studies of the adsorption behavior of serum proteins on titanium. Langmuir, 2000, 16(12): 5449-5457.

[22] Contu F. The cathodic behavior of titanium: serum effect. J Biomed Mater Res Part B Appl Biomater, 2012, 100(2): 544-552.

[23] Padilla N, Bronson A. Electrochemical characterization of albumin protein on Ti–6Al–4V alloy immersed in a simulated plasma solution. J Biomed Mater Res A, 2007, 81(3): 531-543.

[24] Contu F, Elsener B, Bohni H. Serum effect on the electrochemical behaviour of titanium, Ti6A14V and Ti6Al7Nb alloys in sulphuric acid and sodium hydroxide. Corros Sci, 2004, 46(9): 2241-2254.

[25] Barão VA, Mathew MT, Assunção WG. The role of lipopolysaccharide on the electrochemical behavior of titanium. J Dent Res, 2011, 90(5): 613-618.

[26] Mathew MT, Barão VA, Yuan JC. What is the role of lipopolysaccharide on the tribocorrosive behavior of titanium. J Mech Behav Biomed Mater, 2012, 8: 71-85.

[27] Ragab AA, van de Motter R, Lavish SA. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces. J Orthop Res, 1999, 17(6): 803-809.

[28] Strietzel R, Hösch A, Kalbfleisch H. In vitro corrosion of titanium. Biomaterials, 1998, 19(16): 1495-1499.

[29] Okazaki Y, Gotoh E. Comparison of metal release from various metallic biomaterials in vitro. Biomaterials, 2005, 26(1): 11-21.

[30] Pan J, Thierry D, Leygraf C. Electrochemical impedance spectroscopy study of the passive oxide film on titanium for implant application. Electrochim Acta, 1996, 41(7/8): 1143-1153.

[31] May TW, Wiedmeyer RH. A table of polyatomic interferences in ICP-MS. Atom Spectrosc, 1998, 19(5): 150-155.

[32] Schromm AB, Brandenburg K, Loppnow H. The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity. J Immunol, 1998, 161(10): 5464-5471.

[33] Garidel P, Rappolt M, Schromm AB. Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity. Biochim Biophys Acta, 2005, 1715(2): 122-131.

[34] Sourek J, Tichý M, Levin J. Effects of certain cations (Fe, Zn, Mg, and Ca) on bacterial endotoxins. Infect Immun, 1978, 21(2): 648-654.

[35] Coughlin RT, Tonsager S, McGroarty EJ. Quantitation of metal cations bound to membranes and extracted lipopolysaccharide of Escherichia coli. Biochemistry, 1983, 22(8): 2002-2007.