Chlorogenic acid alters the voltage-gated potassium channel currents of trigeminal ganglion neurons

Abstract

A plant-derived compound with therapeutic potential may inhibit pain signals through its effects on specific nerve cell proteins. Scientists have recently begun exploring the anti-cancer, anti-inflammatory and neurological effects of chlorogenic acid (CGA), a molecule produced by bamboo and other plants. Jie-Fei Shen and colleagues at Sichuan University in China examined the effects of CGA on two ‘potassium-gated voltage channel’ (K_V) proteins, which participate in nerve cell signaling. The researchers examined cells from the rat trigeminal ganglion, a nervous system structure that detects and responds to pain. CGA increased the activity of both K_V proteins, and Shen and colleagues predict that the resulting response would gradually dampen trigeminal pain signaling. These findings could assist the development of drugs that block the severe discomfort associated with inflammatory and neuropathic pain.

Keywords

chlorogenic acid / trigeminal ganglion neuron / voltage-gated potassium channel / whole-cell patch clamp

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