An evaluation of the inflammatory response of lipopolysaccharide-treated primary dental pulp cells with regard to calcium silicate-based cements

Abstract

A new cement for tooth root repair may offer better biocompatibility and lower risk of inflammation than currently used materials. Mineral trioxide aggregate (MTA) has proven highly effective for endodontic repair procedures, but Ming-You Shie and colleagues at Taiwan’s Chung Shan Medical University have developed a calcium silicate (CS) cement that may prove safer. To simulate conditions in the mouth, they cultured dental pulp cells on both MTA and CS, and exposed them to a toxic compound produced by oral bacteria. Cells cultured on MTA exhibited an elevated and prolonged inflammatory response, possibly arising from silicon released from MTA. In contrast, cells cultured on CS showed improved viability and reduced inflammation over time. The researchers propose that this new cement may offer a useful alternative to MTA.

Keywords

calcium silicate cement / dental pulp cell / mineral trioxide aggregate / immune response / interleukin-1β

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