The clinical effectiveness of reflectance optical spectroscopy for the in vivo diagnosis of oral lesions

Abstract

A screening tool that uses multispectral light can help clinicians and dentists discriminate between oral cancer and other mouth diseases. The Identafi device uses three different types of light to diagnose abnormalities in the oral mucosa. Standard examinations of mouth lesions can be made with white light; violet light reveals tissue fluorescence and amber-green light can then reveal differences in blood supply between healthy and diseased tissues. Diana Messadi and her colleagues at the University of California, Los Angeles, School of Dentistry, USA, tested the device in 21 people with various oral lesions. The researchers also took tissue biopsies and measured levels of CD34, a marker for endothelial cells. They showed the reflectance of green-amber light correlated with the degree of cellular abnormality. This pilot study supports the use of Identafi for detecting cancerous and precancerous oral lesions.

Keywords

angiogenesis / optical spectroscopy / oral lesions

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