Expression of cyclin-dependent kinase inhibitor 2A 16, tumour protein 53 and epidermal growth factor receptor in salivary gland carcinomas is not associated with oncogenic virus infection

Abstract

Viruses that have been linked with various cancers of the head and neck do not appear to play a role in salivary gland tumors. Certain subtypes of human papilloma virus (HPV), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) can disrupt cellular signaling in a way that promotes uncontrolled growth. Infections with these viruses are common in certain tumors of the mouth, nose and throat. Kais Hussein’s team at Hannover Medical School in Germany searched for viruses in tissue samples of salivary gland tumors from 77 patients. HPV, EBV and CMV were not present in any of the samples, regardless of tumor type and whether a tumor was benign or malignant. The researchers observed abnormal activity in the signaling pathways normally affected by these viruses but concluded that these changes arose from other physiological disruptions.

Keywords

cyclin-dependent kinase inhibitor 2A / human papillomavirus / salivary gland carcinoma

References

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