Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion

Abstract

Stem cells injected into damaged salivary glands help promote tissue healing, according to a study in rats. A team led by Nicole Rotter from the Ulm University Medical Center, Germany, surgically injured submandibular salivary glands in rats. The researchers then injected mesenchymal stem cells (MSCs) derived from a rat bone marrow cell line into the tail veins. They observed a migration of the stem cells into both healthy and damaged salivary glands. Rotter and her colleagues also injected the MSCs directly into the rats' salivary glands, where the stem cells recruited immune cells, including leukocytes and macrophages, to the site of injury. MSC therapy thus promotes beneficial immune responses and could help people overcome the dry mouth side effects that result from salivary gland damage associated with radiation administered for head and neck cancer.

Keywords

duct ligation / mesenchymal stem cells / submandibular gland injury / xerostomia

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