Comparative study of chitosan/fibroin–hydroxyapatite and collagen membranes for guided bone regeneration in rat calvarial defects: micro-computed tomography analysis

Abstract

Bone healing after oral surgery could be enhanced by new biodegradable membranes for reconstruction, according to research from South Korea. The search for non-toxic, biodegradable and hypoallergenic membranes to guide oral bone reconstruction after surgery is on-going. Current membranes are made from collagen. Sang Hun Shin and co-workers at Pusan National University have created a new membrane (named CFB-HAP) incorporating the natural polysaccharide chitosan, a structural protein from silk called fibroin, and hydroxyapatite, a component of natural bone. In a study comparing the effectiveness of CFB-HAP with collagen membranes, the team used microscopic computerized tomography to investigate new bone formation in rats. The images showed that CFB-HAP performed as well as existing membranes in terms of increasing bone volume and mineral density following oral surgery.

Keywords

chitosan/fibroin–hydroxyapatite / collagen membrane / guided bone regeneration / micro-computed tomography / rat calvarial defect

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