Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis

Abstract

Gene expression profiling reveals how surrounding tissues may the promote growth of a benign but aggressive class of oral tumor. The process by which keratocystic odontogenic tumors (KCOT) develop is poorly understood, but evidence suggests that KCOT cells receive important cues from the stromal cells that surround the tumor. Researchers led by Tie-Jun Li and Feng Chen of China’s Peking University School and Hospital of Stomatology analyzed and compared the gene activity in KCOT stromal tissue with healthy samples. They identified a secreted protein, LOXL4, which is produced at considerably elevated levels in KCOT samples. Preliminary functional analysis suggests that LOXL4 can stimulate blood vessel growth, and may also promote proliferation and invasive growth in endothelial cells. These findings thus illustrate one possible mechanism by which cells in the tumor environment could stimulate KCOT formation and expansion.

Keywords

angiogenesis / keratocystic odontogenic tumor / lysyl oxidase-like 4 / RNA-sequencing / tumor stromal fibroblast

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