KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells

Abstract

A protein that regulates bone development may offer a useful target for promoting stem cell-mediated dental regeneration, report dental scientists in the US and China. The jaw contains multiple mesenchymal stem cell (MSC) populations that have the capacity to develop into a variety of mature cell types. Scientists see great potential in using these cells to repair dental damage, but they require a thorough understanding of how MSC’s development is coordinated. Christine Hong and Cun-Yu Wang of the University of California at Los Angeles have identified a protein that directly facilitates bone formation in dentally derived MSCs. They demonstrated that the enzyme KDM6B activates several genes that facilitate the transformation of MSCs into mature bone tissue. They also showed that this process is essentially blocked in the absence of KDM6B, confirming this protein’s critical role in stem cell based dental repair.

Keywords

bone morphogenic protein / dental mesenchymal stem cell / epigenetics / KDM6B / odontogenic differentiation

References

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