Expression of cellular fibronectin mRNA in adult periodontitis and peri-implantitis: a real-time polymerase chain reaction study

Abstract

Different diseases of the specialized tissues that surround and support teeth, the periodontium, result in different expression levels of the gene that encodes a key structural component, the glycoprotein cellular fibronectin (cFn). Guo-Min Ou and colleagues at Sichuan University in Chengdu, China, measured expression levels of cFn RNA in 30 people: 10 with periodontitis, inflammation around the teeth; 10 with peri-implantitis, inflammation around dental implants; and 10 with no periodontal problems. The researchers found that transcription of cFn in the periodontitis group was significantly lower than that in the healthy group. In contrast, the mRNA expression of cFn in the peri-implantitis cohort was higher than that in the healthy individuals. Although both inflammatory diseases of the periodontium share many features, the findings indicate that the underlying pathology is driven, at least partially, by unique molecular mechanisms.

Keywords

adult periodontitis / cellular fibronectin / peri-implantitis / real-time polymerase chain reaction

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