Unusual presentation of localized gingival enlargement associated with a slow-growing odontogenic myxoma

Abstract

Unusual presentation of localized gingival enlargement associated with a subjacent tumoural pathology is reported. The patient was a 55-year-old black male, whose chief complaint was a progressive gingival overgrowth for more than ten years, in the buccal area of the anterior left mandible. According to the clinical features and the radiological diagnosis of odontogenic keratocyst, a conservative surgery with enucleation and curettage was performed. Tissue submitted for histopathological analysis rendered the diagnosis of odontogenic myxoma. After 12-month of follow-up, no evidence of recurrence was found. Clinicians should be cautious when facing any gingival enlargement to avoid diagnostic pitfalls and to indicate the appropriate treatment.

Keywords

gingival enlargement / jaw neoplasm / odontogenic tumour / myxoma / myxofibroma

References

[1] Brunet Ll, Miranda J, Farré M. Gingival enlargement induced by drugs. Drug Saf, 1996, 15(3): 219-231.

[2] Clocheret K, Dekeyser C, Carels C. Idiopathic gingival hyperplasia and orthodontic treatment: a case report. J Orthod, 2003, 30(1): 13-19.

[3] Rodríguez Y, Baena R, Rizzo S. Mandibular traumatic peripheral osteoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(6): 44-48.

[4] Perrotti V, Rubini C, Fioroni M. Soft tissue myxoma; report of an unusual case located on the gingiva. J Clin Periodontol, 2006, 33(1): 76-78.

[5] Rawal YB, Mustiful-Martín D, Rosebush MS. Slow-growing gingival mass. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(2): 161-167.

[6] López Arranz JS, Junquera Gutiérrez LM. Tumores odontogénicos. Generalidades. Clasificación. Formas clínicas. // Bascones A. Tratado de Odontología., 1998 Madrid 3927-3940.

[7] Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: a study of 1088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg, 2006, 64(9): 1343-1352.

[8] Gomes CC, Diniz MG, Duarte AP. Molecular review of odontogenic myxoma. Oral Oncol, 2011, 47(5): 325-328.

[9] Barnes L, Eveson J, Reichart P et al. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Head and Neck. Lyon: IARC, 2005.

[10] Martínez-Mata G, Mosqueda-Taylor A, Carlos-Bregni R. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol, 2008, 44(6): 601-607.

[11] Leiser Y, Abu-El-Naaj I, Peled M. Odontogenic myxoma—a case series and review of the surgical management. J Craniomaxillofac Surg, 2009, 37(4): 206-209.

[12] Boffano P, Gallesio C, Barreca A. Surgical treatment of odontogenic myxoma. J Craniofac Surg, 2011, 22(3): 982-987.

[13] Günhan Ö, Arpak N, Celasun B. Odontogenic myxoma. Report of a periodontally-located case. J Periodontol, 1991, 62(6): 387-389.

[14] Simon EN, Merkx MA, Vuhahula E. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg, 2004, 33(4): 333-337.

[15] Moshiri S, Oda D, Worthington P. Odontogenic myxoma: histochemical and ultrastuctural study. J Oral Pathol Med, 1992, 21(9): 401-403.

[16] Schmidt-Westhausen A, Becker J, Schuppan D. Odontogenic myxoma-characterisation of the extracellular matrix (ECM) of the tumour stroma. Eur J Cancer B Oral Oncol, 1994, 30(6): 377-380.

[17] Zhang J, Wang H, He X. Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol, 2007, 36(3): 160-167.

[18] Noffke CE, Raubenheimer EJ, Chabikuli NJ. Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 104(1): 101-109.

[19] Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg, 2005, 63(6): 811-819.

[20] Albanese M, Nocini PF, Fior A. Mandibular reconstruction using fresh frozen bone allograft after conservative enucleation of a mandibular odontogenic myxoma. J Craniofac Surg, 2012, 23(3): 831-835.

[21] de Macedo LG, de Macedo NL, do Socorro Ferreira Monteiro A. Fresh-frozen human bone graft for repair of defect after adenomatoid odontogenic tumour removal. Cell Tissue Bank, 2009, 10(3): 221-226.

[22] Ali M, Baughman RA. Maxillary odontogenic keratocyst: a common and serious clinical misdiagnosis. J Am Dent Assoc, 2003, 134(7): 877-883.